{"doi":"10.1101/2022.07.31.502241","title":"Origin, Prospective Identification, and Function of Circulating Endothelial Colony Forming Cells in Mouse and Human","abstract":"Summary Most circulating endothelial cells are apoptotic, but rare circulating endothelial colony forming cells (C-ECFCs) with proliferative and vasculogenic activity can be cultured; the origin and naïve function of these C-ECFCs remains obscure. Herein, detailed lineage tracing reveals murine C-ECFCs emerge in the early postnatal period, display high vasculogenic potential, with enriched frequency of clonal proliferative cells compared to tissue-resident ECFCs, and are not committed to or derived from the bone marrow hematopoietic system but from tissue-resident ECFCs. In human subjects, C-ECFCs are present in the CD34 bright cord blood mononuclear subset, possess proliferative potential and in vivo vasculogenic function in a naïve or cultured state, and display a single cell transcriptome sharing some umbilical venous endothelial cell features like, higher Protein C Receptor and extracellular matrix gene expression. This study provides an advance for the field by identifying the origin, naïve function, and antigens to prospectively isolate C-ECFCs for translational studies.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":310628,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.94,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":822837,"name":"Kimihiko Banno","orcid":"0000-0002-1458-0881","position":1,"is_corresponding":false},{"id":1005791,"name":"Chang-Hyun Gil","orcid":"0000-0001-8323-5064","position":2,"is_corresponding":false},{"id":570314,"name":"Jered Myslinski","orcid":"0000-0003-2760-8692","position":3,"is_corresponding":false},{"id":414315,"name":"Takashi Hato","orcid":"0000-0002-0446-6575","position":4,"is_corresponding":false},{"id":427775,"name":"W. Christopher Shelley","orcid":"0000-0003-1609-4198","position":5,"is_corresponding":false},{"id":29086,"name":"Hongyu Gao","orcid":"0000-0001-8633-3604","position":6,"is_corresponding":false},{"id":256234,"name":"Xiaoling Xuei","orcid":"0000-0002-4143-2024","position":7,"is_corresponding":false},{"id":227678,"name":"Yunlong Liu","orcid":"0000-0002-2699-626X","position":8,"is_corresponding":false},{"id":673552,"name":"David P. Basile","orcid":"0000-0003-4649-3464","position":9,"is_corresponding":false},{"id":641028,"name":"Momoko Yoshimoto","orcid":"0000-0002-7272-6682","position":10,"is_corresponding":false},{"id":1006670,"name":"Nutan Prasain","orcid":null,"position":11,"is_corresponding":false},{"id":1005792,"name":"Stefan P. Tarnawsky","orcid":"0000-0002-7970-702X","position":12,"is_corresponding":false},{"id":262888,"name":"Ralf H. Adams","orcid":"0000-0003-3031-7677","position":13,"is_corresponding":false},{"id":1005793,"name":"Katsuhiko Naruse","orcid":"0000-0001-6129-5074","position":14,"is_corresponding":false},{"id":1005794,"name":"Junko Yoshida","orcid":"0000-0001-5003-0214","position":15,"is_corresponding":false},{"id":353351,"name":"Michael P. Murphy","orcid":"0000-0003-3079-0659","position":16,"is_corresponding":false},{"id":1005795,"name":"Kyoji Horie","orcid":"0000-0001-9036-8180","position":17,"is_corresponding":false},{"id":368718,"name":"Mervin C. Yöder","orcid":"0000-0003-4354-7631","position":18,"is_corresponding":false},{"id":237939,"name":"Yang Lin","orcid":"0000-0002-0709-2468","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T00:33:19.712967Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}