{"doi":"10.1101/2022.07.26.22278079","title":"Evoked midfrontal activity predicts cognitive dysfunction in Parkinson’s disease","abstract":"Abstract Cognitive dysfunction is a major feature of Parkinson’s disease (PD), but the pathophysiology remains unknown. One potential mechanism is abnormal low-frequency cortical rhythms which engage cognitive functions and are deficient in PD. We tested the hypothesis that midfrontal delta/theta rhythms predict cognitive dysfunction in PD. We recruited 100 PD patients and 49 demographically-similar control participants who completed a series of cognitive control tasks, including the Simon, oddball, and interval timing tasks. We focused on cue-evoked delta (1-4 Hz) and theta (4-7 Hz) rhythms from a single midfrontal EEG electrode (Cz) in PD patients who were either cognitively normal, with mild-cognitive impairments (PDMCI), or had dementia (PDD). We found that PD-related cognitive dysfunction was associated with increased response latencies and decreased midfrontal delta power across all tasks. Within PD patients, the first principal component of evoked EEG features from a single electrode (Cz) strongly correlated with clinical metrics such as the Montreal Cognitive Assessment (MOCA; rho=0.36) and with NIH-toolbox Executive Function scores (rho=0.46). These data demonstrate that cue-evoked midfrontal delta/theta rhythms directly relate to cognition in PD. Our results provide insight into the nature of low-frequency frontal rhythms and suggest that PD-related cognitive dysfunction results from decreased delta/theta activity. These findings could facilitate the development of new biomarkers and targeted therapies for cognitive symptoms of PD.","journal":"medRxiv","year":2022,"id":298781,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":785658,"name":"Rachel C. Cole","orcid":"0000-0003-4753-0482","position":1,"is_corresponding":false},{"id":806767,"name":"Arturo I. Espinoza","orcid":"0000-0003-4252-3259","position":2,"is_corresponding":false},{"id":364000,"name":"Jan R. Wessel","orcid":"0000-0002-7298-6601","position":3,"is_corresponding":false},{"id":251256,"name":"James F. Cavanagh","orcid":"0000-0003-2428-3562","position":4,"is_corresponding":false},{"id":98533,"name":"Nandakumar S. Narayanan","orcid":"0000-0002-0427-0003","position":5,"is_corresponding":false},{"id":251255,"name":"Arun Singh","orcid":"0000-0003-4273-542X","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T00:31:40.528568Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}