{"doi":"10.1101/2022.07.25.501261","title":"Increased homozygosity due to endogamy results in fitness consequences in a human population","abstract":"Abstract Recessive alleles have been shown to directly affect both human Mendelian disease phenotypes and complex traits like height. Pedigree studies also suggest that consanguinity results in increased childhood mortality and adverse health phenotypes, presumably through penetrance of recessive mutations. Here, we test whether the accumulation of homozygous, recessive alleles decreases reproductive success in a human population. We address this question among the Namibian Himba, an endogamous agro-pastoralist population, who until very recently practiced natural fertility. Using a sample of 681 individuals, we show that Himba exhibit elevated levels of “inbreeding”, calculated as the fraction of the genome in runs of homozygosity (F ROH ). Many individuals contain multiple long segments of ROH in their genomes, indicating that their parents had high kinship coefficients. However, we did not find evidence that this is explained by first-cousin consanguinity, despite a reported social preference for cross-cousin marriages. Rather, we show that elevated haplotype sharing in the Himba is due to a bottleneck, likely in the past 60 generations. We test whether increased recessive mutation load results in observed fitness consequences by assessing the effects of F ROH on completed fertility in a cohort of post-reproductive women (n=69). We find that higher F ROH is significantly associated with lower fertility among women who have had at least one child (p<0.006). Our data suggest a multi-locus genetic effect on fitness driven by the expression of deleterious recessive alleles, especially those in long ROH. However, these effects are not the result of consanguinity but rather elevated background identity by descent.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":298327,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":311070,"name":"Sean P. Prall","orcid":"0000-0001-5719-6460","position":1,"is_corresponding":false},{"id":987301,"name":"Christine M. Williams","orcid":"0000-0001-9187-4851","position":2,"is_corresponding":false},{"id":311075,"name":"Jacob Sheehama","orcid":"0000-0001-5085-6606","position":3,"is_corresponding":false},{"id":311069,"name":"Brooke A. Scelza","orcid":"0000-0001-5875-8875","position":4,"is_corresponding":false},{"id":62191,"name":"Brenna M. Henn","orcid":"0000-0003-4998-287X","position":5,"is_corresponding":false},{"id":311071,"name":"Natalie Swinford","orcid":"0000-0001-6414-8555","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:31:36.269611Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}