{"doi":"10.1101/2022.07.19.500711","title":"Multi-omics reveal <i>Salmonella</i> -liberated dietary L-arabinose promotes expansion in superspreaders","abstract":"SUMMARY Our understanding of specific metabolites that drive host-pathogen interactions in the guts of superspreader hosts is incomplete. In a mouse model of chronic, asymptomatic Salmonella enterica serovar Typhimurium ( S . Tm) infection, we performed untargeted metabolomics on the feces of mice and found superspreader hosts possess distinct metabolic signatures compared to non-superspreaders, including differential levels of L-arabinose. RNA-seq on S . Tm in superspreader fecal samples showed increased expression of the L-arabinose catabolism pathway in vivo . By combining bacterial genetics and diet manipulation, we demonstrate that diet-derived L-arabinose provides S . Tm a competitive advantage in the gut. We show that expansion of S . Tm in the gut requires a previously uncharacterized alpha-N-arabinofuranosidase that can liberate L-arabinose from dietary polysaccharides. Ultimately, we demonstrate that pathogen-liberated L-arabinose from the diet provides a competitive advantage to S . Tm in vivo . These findings propose L-arabinose as a critical driver of S . Tm expansion in the guts of superspreader hosts.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":309931,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":398580,"name":"Liliana M. Massis","orcid":null,"position":1,"is_corresponding":false},{"id":294959,"name":"Alyssa C. Cutter","orcid":"0000-0002-7426-7045","position":2,"is_corresponding":false},{"id":350838,"name":"Denise M. Monack","orcid":"0000-0003-3804-2209","position":3,"is_corresponding":false},{"id":1005096,"name":"Sarah Ruddle","orcid":"0000-0003-2799-1222","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T00:33:15.860993Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}