{"doi":"10.1101/2022.07.18.22277255","title":"90K/ <i>LGALS3BP</i> Expression is Upregulated in COVID-19 but Does Not Restrict SARS-CoV-2 Infection","abstract":"Abstract Glycoprotein 90K, encoded by the interferon-stimulated gene LGALS3BP , displays broad antiviral activity. It reduces HIV-1 infectivity by interfering with Env maturation and virion incorporation, and increases survival of Influenza A virus-infected mice via antiviral innate immune signaling. Here, we analyzed the expression of 90K/ LGALS3BP in 44 hospitalized COVID-19 patients. 90K protein serum levels were significantly elevated in COVID-19 patients compared to uninfected sex- and age-matched controls. Furthermore, PBMC-associated concentrations of 90K protein were overall reduced by SARS-CoV-2 infection in vivo, suggesting enhanced secretion into the extracellular space. Mining of published PBMC scRNA-seq datasets uncovered monocyte-specific induction of LGALS3BP mRNA expression in COVID-19 patients. In functional assays, neither 90K overexpression in susceptible cell lines nor exogenous addition of purified 90K consistently inhibited SARS-CoV-2 infection. Our data suggests that 90K/ LGALS3BP contributes to the global type I IFN response during SARS-CoV-2 infection in vivo without displaying detectable antiviral properties.","journal":"medRxiv","year":2022,"id":309934,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9608,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1005097,"name":"Bengisu Akbil","orcid":"0000-0002-1263-4313","position":1,"is_corresponding":false},{"id":1005098,"name":"Johanna Leyens","orcid":"0009-0009-1689-4751","position":2,"is_corresponding":false},{"id":566946,"name":"Dylan Postmus","orcid":"0000-0002-9551-0411","position":3,"is_corresponding":false},{"id":1005391,"name":"Greta Harnisch","orcid":null,"position":4,"is_corresponding":false},{"id":567873,"name":"Jenny Jansen","orcid":null,"position":5,"is_corresponding":false},{"id":230502,"name":"Marie Luisa Schmidt","orcid":"0000-0002-8512-7531","position":6,"is_corresponding":false},{"id":618094,"name":"Annette Aigner","orcid":"0000-0003-4891-8921","position":7,"is_corresponding":false},{"id":57958,"name":"Fabian Pott","orcid":"0000-0003-3700-1691","position":8,"is_corresponding":false},{"id":57946,"name":"Robert Lorenz Chua","orcid":"0000-0001-5945-9957","position":9,"is_corresponding":false},{"id":1005099,"name":"Lilian Krist","orcid":"0000-0002-6089-5163","position":10,"is_corresponding":false},{"id":1005100,"name":"Roberta Gentile","orcid":"0000-0002-6731-0113","position":11,"is_corresponding":false},{"id":615722,"name":"Barbara Mühlemann","orcid":"0000-0002-5314-8530","position":12,"is_corresponding":false},{"id":615720,"name":"Terry C. 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