{"doi":"10.1101/2022.07.17.499189","title":"MAIT cells have a negative impact on glioblastoma","abstract":"Abstract Glioblastoma (GBM) is the most aggressive primary brain cancer in adults and remains incurable. Our study revealed an immunosuppressive role of mucosal-associated invariant T (MAIT) cells in GBM. In bulk RNA sequencing data analysis of GBM tissues, MAIT cell gene signature significantly correlated with poor patient survival. A scRNA-seq of CD45 + cells from 23 GBM tissue samples showed 15 (65.2%) were positive for MAIT cells and the enrichment of MAIT17. The MAIT cell signature significantly correlated with the activity of tumor-associated neutrophils (TANs) and myeloid-derived suppressor cells (MDSCs). Multiple immune suppressive genes known to be used by TANs/MDSCs were upregulated in MAIT-positive tumors. Spatial imaging analysis of GBM tissues showed that all specimens were positive for both MAIT cells and TANs and localized enrichment of TANs. These findings highlight the MAIT-TAN/MDSC axis as a novel therapeutic target to modulate GBM’s immunosuppressive tumor microenvironment.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":303834,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":996246,"name":"Taijun Hana","orcid":"0000-0001-7649-3305","position":1,"is_corresponding":false},{"id":620588,"name":"Alex Lee","orcid":"0000-0002-4583-0740","position":2,"is_corresponding":false},{"id":996710,"name":"Noemi Kedei","orcid":null,"position":3,"is_corresponding":false},{"id":996711,"name":"Nargis Malik","orcid":null,"position":4,"is_corresponding":false},{"id":585513,"name":"Hye Min Kim","orcid":"0000-0002-2899-9480","position":5,"is_corresponding":false},{"id":996712,"name":"Jo Spurgeon","orcid":null,"position":6,"is_corresponding":false},{"id":402726,"name":"Guzal Khayrullina","orcid":"0000-0002-9130-4274","position":7,"is_corresponding":false},{"id":232861,"name":"Benjamin Ruf","orcid":"0000-0002-2501-4471","position":8,"is_corresponding":false},{"id":996713,"name":"Ayaka Hara","orcid":null,"position":9,"is_corresponding":false},{"id":996714,"name":"Morgan Coombs","orcid":null,"position":10,"is_corresponding":false},{"id":996715,"name":"Matthew Watowich","orcid":null,"position":11,"is_corresponding":false},{"id":920624,"name":"Ananth Hari","orcid":"0000-0001-8174-5335","position":12,"is_corresponding":false},{"id":921203,"name":"Michael K.B. Ford","orcid":null,"position":13,"is_corresponding":false},{"id":996716,"name":"Cenk Sahinalp","orcid":null,"position":14,"is_corresponding":false},{"id":463380,"name":"Masashi Watanabe","orcid":"0000-0003-1741-8748","position":15,"is_corresponding":false},{"id":404282,"name":"George Zaki","orcid":"0000-0002-2740-3307","position":16,"is_corresponding":false},{"id":109755,"name":"Mark R. Gilbert","orcid":"0000-0003-2556-9722","position":17,"is_corresponding":false},{"id":996717,"name":"Patrick. J. Cimino","orcid":null,"position":18,"is_corresponding":false},{"id":275829,"name":"Robert M. Prins","orcid":"0000-0002-6282-6583","position":19,"is_corresponding":false},{"id":372492,"name":"Masaki Terabe","orcid":"0000-0002-1777-0189","position":20,"is_corresponding":false},{"id":996709,"name":"Seketoulie Keretsu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-19T00:32:28.468841Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}