{"doi":"10.1101/2022.07.13.499820","title":"<i>RLSuite</i> : An integrative R-loop bioinformatics framework","abstract":"ABSTRACT R-loops are three-stranded nucleic acid structures containing RNA:DNA hybrids. While R-loop mapping via high-throughput sequencing can reveal novel insight into R-loop biology, the analysis and quality control of these data is a non-trivial task for which few bioinformatic tools exist. Herein we describe RLSuite , an integrative R-loop bioinformatics framework for pre-processing, quality control, and downstream analysis of R-loop mapping data. RLSuite enables users to compare their data to hundreds of public datasets and generate a user-friendly analysis report for sharing with non-bioinformatician colleagues. Taken together, RLSuite is a novel analysis framework that should greatly benefit the emerging R-loop bioinformatics community.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":309847,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":292965,"name":"Daniel Montemayor","orcid":"0000-0001-8702-5646","position":1,"is_corresponding":false},{"id":813345,"name":"Simon A. Levy","orcid":"0000-0002-4623-5716","position":2,"is_corresponding":false},{"id":292969,"name":"Kumar Sharma","orcid":"0000-0002-7550-8525","position":3,"is_corresponding":false},{"id":79790,"name":"Bess Frost","orcid":"0000-0002-1212-8138","position":4,"is_corresponding":false},{"id":97807,"name":"Alexander J.R. Bishop","orcid":"0000-0002-5742-4387","position":5,"is_corresponding":false},{"id":310418,"name":"Henry E. Miller","orcid":"0000-0003-3756-3918","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:33:15.860993Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}