{"doi":"10.1101/2022.07.06.499007","title":"IBD-based estimation of X chromosome effective population size with application to sex-specific demographic history","abstract":"Abstract The effective size of a population ( N e ) in the recent past can be estimated through analysis of identity-by-descent (IBD) segments. Several methods have been developed for estimating N e from autosomal IBD segments, but no such effort has been made with X chromosome IBD segments. In this work, we propose a method to estimate the X chromosome effective population size from X chromosome IBD segments. We show how to use the estimated autosome N e and X chromosome N e to estimate female and male effective population sizes. We demonstrate the accuracy of our autosome and X chromosome N e estimation with simulated data. We find that estimated female and male effective population sizes generally reflect the simulated sex-specific effective population sizes across the past 100 generations, but that short-term differences between the estimated sex-specific N e across tens of generations may not reliably indicate true sex-specific differences. We analyzed the effective size of populations represented by samples of sequenced UK White British and UK Indian individuals from the UK Biobank.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":301519,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":35168,"name":"Brian L. Browning","orcid":"0000-0001-6454-6633","position":1,"is_corresponding":false},{"id":245900,"name":"Sharon R. Browning","orcid":"0000-0001-7251-9715","position":2,"is_corresponding":false},{"id":904679,"name":"Ruoyi Cai","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-19T00:32:02.193874Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}