{"doi":"10.1101/2022.07.05.498856","title":"Learning alters neural activity to simultaneously support memory and action","abstract":"Abstract How are we able to learn new behaviors without disrupting previously learned ones? To understand how the brain achieves this, we used a brain-computer interface (BCI) learning paradigm, which enables us to detect the presence of a memory of one behavior while performing another. We found that learning to use a new BCI map altered the neural activity that monkeys produced when they returned to using a familiar BCI map, in a way that was specific to the learning experience. That is, learning left a “memory trace.” This memory trace co-existed with proficient performance under the familiar map, primarily by altering dimensions of neural activity that did not impact behavior. Such a memory trace could provide the neural underpinning for the joint learning of multiple motor behaviors without interference.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":297141,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":560371,"name":"Jay A. Hennig","orcid":"0000-0001-7982-8553","position":1,"is_corresponding":false},{"id":560372,"name":"Emily R. Oby","orcid":"0000-0002-3376-0669","position":2,"is_corresponding":false},{"id":556239,"name":"Matthew D. Golub","orcid":"0000-0003-4508-0537","position":3,"is_corresponding":false},{"id":561177,"name":"Patrick T. Sadtler","orcid":null,"position":4,"is_corresponding":false},{"id":560374,"name":"Kristin M. Quick","orcid":"0000-0003-4028-2463","position":5,"is_corresponding":false},{"id":290907,"name":"Stephen I. Ryu","orcid":"0000-0002-4607-7447","position":6,"is_corresponding":false},{"id":481525,"name":"Elizabeth C. Tyler‐Kabara","orcid":"0000-0003-3286-1094","position":7,"is_corresponding":false},{"id":560375,"name":"Aaron P. Batista","orcid":"0000-0002-1719-0061","position":8,"is_corresponding":false},{"id":258913,"name":"Byron M. Yu","orcid":"0000-0003-2252-6938","position":9,"is_corresponding":false},{"id":560376,"name":"Steven M. Chase","orcid":"0000-0003-4450-6313","position":10,"is_corresponding":false},{"id":985097,"name":"Darby M. Losey","orcid":null,"position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:31:21.257700Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}