{"doi":"10.1101/2022.06.30.498297","title":"Acetaminophen production in the edible, filamentous cyanobacterium <i>Arthrospira platensis</i>","abstract":"Abstract Spirulina is the common name for the edible, non-heterocystous, filamentous cyanobacterium Arthrospira platensis that is grown industrially as a food supplement, animal feedstock, and pigment source. Although there are many applications for engineering this organism 1–3 , until recently no genetic tools or reproducible transformation methods have been published. While recent work showed the production of a diversity of proteins in A. platensis , including single domain antibodies for oral delivery, there remains a need for a modular, characterized genetic toolkit 4 . Here, we establish and characterize a genetic toolkit and reproducible method for the transformation of A. platensis and engineer this bacterium to produce acetaminophen as proof-of-concept for small molecule production in an edible host from CO 2 , H 2 O, and light. This work opens A. platensis to the wider scientific community for future engineering as a functional food for nutritional enhancement, modification of organoleptic traits, and production of pharmaceuticals for oral delivery.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":303747,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.947,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":668397,"name":"Skyler Friedline","orcid":"0000-0002-1027-7631","position":1,"is_corresponding":false},{"id":996668,"name":"Divya Sivanandan","orcid":null,"position":2,"is_corresponding":false},{"id":996669,"name":"Ya-Fang Cheng","orcid":null,"position":3,"is_corresponding":false},{"id":996165,"name":"Shunsuke Yamazaki","orcid":"0009-0001-5507-8724","position":4,"is_corresponding":false},{"id":412247,"name":"Douglas S. Clark","orcid":"0000-0003-1516-035X","position":5,"is_corresponding":false},{"id":356772,"name":"Jeffrey M. Skerker","orcid":"0000-0003-2653-1566","position":6,"is_corresponding":false},{"id":2171,"name":"Adam P. Arkin","orcid":"0000-0002-4999-2931","position":7,"is_corresponding":false},{"id":996164,"name":"Jacob M. Hilzinger","orcid":"0000-0002-1876-1313","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T00:32:28.468841Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}