{"doi":"10.1101/2022.06.20.22276414","title":"First Point-of-Care Diagnostic Test for Beta-Thalassemia","abstract":"ABSTRACT Hemoglobin (Hb) disorders are among the most common monogenic diseases affecting nearly 7% of the world’s population. Among various Hb disorders, approximately 1.5% of the world population carry β -thalassemia ( β -Thal), affecting 40,000 newborns every year. Early screening and timely diagnosis are essential in β -thalassemia patients for prevention and management of later clinical complications. However, in Africa to Southern Europe, Middle East, and Southeast Asia, where β -thalassemia is most prevalent, diagnosis and screening of β -thalassemia is still challenging due to the cost and logistical burden of laboratory diagnostic tests. Here, we present Gazelle, a paper-based microchip electrophoresis platform, that enables the first point-of-care diagnostic test for β -thalassemia. We evaluated the accuracy of Gazelle for β -Thal screening in 372 subjects in the age range of 4 – 63 years at Apple Diagnostics labin Mubai, India. Additionally, 30 blood samples were prepared to mimic β -Thal intermediate and β -Thal major samples. The Gazelle detected levels of Hb A, Hb F, and Hb A 2 demonstrated high correlations with the results reported by the laboratory gold standard, high performance liquid chromatography (HPLC) yielding a Pearson Correlation Coefficient = 0.99. The ability to obtain rapid and accurate results suggest that Gazelle can be suitable for large-scale screening and diagnosis of β -Thal.","journal":"medRxiv","year":2022,"id":309464,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":821370,"name":"Alireza Avanaki","orcid":"0000-0002-7145-5921","position":1,"is_corresponding":false},{"id":307422,"name":"Priyaleela Thota","orcid":"0000-0001-9371-9409","position":2,"is_corresponding":false},{"id":1004779,"name":"Sai Nemade","orcid":null,"position":3,"is_corresponding":false},{"id":1004780,"name":"Amrish Mehta","orcid":null,"position":4,"is_corresponding":false},{"id":307428,"name":"Umut A. Gürkan","orcid":"0000-0002-0331-9960","position":5,"is_corresponding":false},{"id":307415,"name":"Ran An","orcid":"0000-0002-4849-0120","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-19T00:33:11.579763Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}