{"doi":"10.1101/2022.06.06.22275981","title":"α2,6-Sialylation is Upregulated in Severe COVID-19 Implicating the Complement Cascade","abstract":"Better understanding of the mechanisms of COVID-19 severity is desperately needed in current times. Although hyper-inflammation drives severe COVID-19, precise mechanisms triggering this cascade and what role glycosylation might play therein is unknown. Here we report the first high-throughput glycomic analysis of COVID-19 plasma samples and autopsy tissues. We find α2,6-sialylation is upregulated in plasma of patients with severe COVID-19 and in the lung. This glycan motif is enriched on members of the complement cascade, which show higher levels of sialylation in severe COVID-19. In the lung tissue, we observe increased complement deposition, associated with elevated α2,6-sialylation levels, corresponding to elevated markers of poor prognosis (IL-6) and fibrotic response. We also observe upregulation of the α2,6-sialylation enzyme ST6GAL1 in patients who succumbed to COVID-19. Our work identifies a heretofore undescribed relationship between sialylation and complement in severe COVID-19, potentially informing future therapeutic development.","journal":"medRxiv","year":2022,"id":300180,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":459616,"name":"Emma Kurz","orcid":"0000-0001-8251-5224","position":1,"is_corresponding":false},{"id":574975,"name":"Shuhui Chen","orcid":"0000-0001-7255-0026","position":2,"is_corresponding":false},{"id":388871,"name":"Briana Zeck","orcid":"0000-0003-1864-4034","position":3,"is_corresponding":false},{"id":990628,"name":"Luis Chiribogas","orcid":null,"position":4,"is_corresponding":false},{"id":990629,"name":"Dana Jackson","orcid":null,"position":5,"is_corresponding":false},{"id":990370,"name":"Alex Herchen","orcid":"0000-0001-9421-0428","position":6,"is_corresponding":false},{"id":990630,"name":"Tyson Attia","orcid":null,"position":7,"is_corresponding":false},{"id":808875,"name":"Michael A. Carlock","orcid":"0000-0003-4077-7386","position":8,"is_corresponding":false},{"id":225660,"name":"Amy Rapkiewicz","orcid":"0000-0002-3438-022X","position":9,"is_corresponding":false},{"id":230923,"name":"Dafna Bar‐Sagi","orcid":"0000-0003-2597-8948","position":10,"is_corresponding":false},{"id":990371,"name":"Bruce Ritchie","orcid":"0000-0003-4754-1050","position":11,"is_corresponding":false},{"id":245069,"name":"Ted M. Ross","orcid":"0000-0003-1947-7469","position":12,"is_corresponding":false},{"id":456104,"name":"Lara K. Mahal","orcid":"0000-0003-4791-8524","position":13,"is_corresponding":false},{"id":826638,"name":"Rui Qin","orcid":"0000-0001-5822-3985","position":0,"is_corresponding":true}],"reference_count":96,"raw_metadata":null,"created_at":"2026-07-19T00:31:49.412501Z","pmid":"35702159","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}