{"doi":"10.1101/2022.05.24.493318","title":"Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies","abstract":"Abstract An effective malaria vaccine remains a global health priority and vaccine immunogens which prevent transmission of the parasite will have important roles in multi-component vaccines. One of the most promising candidates for inclusion in a transmission-blocking malaria vaccine is the gamete surface protein Pfs48/45, which is essential for development of the parasite in the mosquito midgut. Indeed, antibodies which bind Pfs48/45 can prevent transmission if ingested with the parasite as part of the mosquito bloodmeal. Here we present the first structure of full-length Pfs48/45, revealing its three domains to form a dynamic, planar, triangular arrangement. From this, we show where transmission-blocking and non-blocking antibodies bind on Pfs48/45. Finally, we demonstrate that antibodies which bind across this molecule can be transmission-blocking. These studies will guide the development of future Pfs48/45-based vaccine immunogens.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":298685,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":873737,"name":"F. Lennartz","orcid":"0000-0001-5617-5502","position":1,"is_corresponding":false},{"id":669633,"name":"David Mekhaiel","orcid":"0000-0001-9338-811X","position":2,"is_corresponding":false},{"id":873738,"name":"Bora Guloglu","orcid":"0000-0002-4180-4940","position":3,"is_corresponding":false},{"id":669632,"name":"Arianna Marini","orcid":"0000-0003-3416-7362","position":4,"is_corresponding":false},{"id":873739,"name":"Danielle Deuker","orcid":"0000-0002-2716-4342","position":5,"is_corresponding":false},{"id":324086,"name":"Carole A. Long","orcid":"0000-0002-3835-5443","position":6,"is_corresponding":false},{"id":455393,"name":"Matthijs M. Jore","orcid":"0000-0002-0686-370X","position":7,"is_corresponding":false},{"id":329084,"name":"Kazutoyo Miura","orcid":"0000-0003-4455-2432","position":8,"is_corresponding":false},{"id":669636,"name":"Sumi Biswas","orcid":"0000-0001-8507-7282","position":9,"is_corresponding":false},{"id":471468,"name":"Matthew K. Higgins","orcid":"0000-0002-2870-1955","position":10,"is_corresponding":false},{"id":873736,"name":"Kuang-Ting Ko","orcid":"0000-0003-0328-1808","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:36.269611Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}