{"doi":"10.1101/2022.05.17.492235","title":"OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice","abstract":"Abstract Allergic asthma is a complex disease characterized by dyspnea, coughing, chest tightness and airway remodeling, for which there is no cure and is symptomatically treated with inhaled β2-agonist and/or corticosteroids. Molecular mechanisms underlying its complex pathogenesis are not fully understood. However, the 8-oxoguanine DNA glycosylase-1 (OGG1), a DNA repair protein may play a central role, as OGG1 deficiency decreases both innate and allergic inflammatory responses. In this study, administration of TH5487 to mice with OVA-induced allergic airway inflammation significantly decreased goblet cell hyperplasia and mucus production. TH5487 treatment also decreased levels of activated NF-κB and expression of proinflammatory cytokines resulting in significantly lower recruitment of eosinophils and other immune cells to the lungs. Gene expression profiling of asthma and allergy-related proteins after TH5487 treatment revealed down regulation of Arg1, Mcp1 and Ccl11, and upregulation of the negative regulator of T H 2, Bcl6. In addition, the OVA-induced airway hyperresponsiveness was significantly reduced by TH5487 treatment. Taken together, the data presented in this study suggest a clinically relevant utilization of TH5487 for the treatment of allergic inflammation. Graphical abstract","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":308658,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":898175,"name":"Jesper Bergwik","orcid":"0000-0002-0737-2232","position":1,"is_corresponding":false},{"id":1003880,"name":"Ravi KV Bhongir","orcid":null,"position":2,"is_corresponding":false},{"id":826385,"name":"Lang Pan","orcid":"0000-0003-2324-2144","position":3,"is_corresponding":false},{"id":898952,"name":"Caijuan Dong","orcid":null,"position":4,"is_corresponding":false},{"id":898178,"name":"Christina Kalderén","orcid":"0000-0001-7004-7048","position":5,"is_corresponding":false},{"id":320616,"name":"Thomas Helleday","orcid":"0000-0002-7384-092X","position":6,"is_corresponding":false},{"id":724067,"name":"István Boldogh","orcid":"0000-0002-0088-1130","position":7,"is_corresponding":false},{"id":898179,"name":"Mikael Adner","orcid":"0000-0003-1634-4759","position":8,"is_corresponding":false},{"id":898180,"name":"Arne Egesten","orcid":"0000-0001-5269-3433","position":9,"is_corresponding":false},{"id":898174,"name":"Lloyd Tanner","orcid":"0000-0003-0626-9820","position":0,"is_corresponding":true}],"reference_count":79,"raw_metadata":null,"created_at":"2026-07-19T00:33:07.132912Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}