{"doi":"10.1101/2022.05.16.492224","title":"<i>In-vivo</i> detection of cyclic-di-AMP in <i>Staphylococcus aureus</i>","abstract":"ABSTRACT Cyclic-di-AMP (CDA) is a signaling molecule that controls various cellular functions including antibiotic tolerance and osmoregulation in Staphylococcus aureus . In this study, we developed a novel biosensor ( bsuO P6-4) for in-vivo detection of CDA in S. aureus . Our study showed that bsuO P6-4 could detect a wide concentration range of CDA in both laboratory and clinical strains making it suitable for use in both basic and clinical research applications.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":308620,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":735239,"name":"Raymond Poon","orcid":"0000-0002-6547-6013","position":1,"is_corresponding":false},{"id":1003133,"name":"Philipp N. Sander","orcid":"0000-0001-9176-2649","position":2,"is_corresponding":false},{"id":925074,"name":"Li-Yin Lai","orcid":null,"position":3,"is_corresponding":false},{"id":933784,"name":"Zahra Zubair-Nizami","orcid":"0009-0005-6078-880X","position":4,"is_corresponding":false},{"id":522388,"name":"Ming C. Hammond","orcid":"0000-0003-2666-4764","position":5,"is_corresponding":false},{"id":388562,"name":"Som S. Chatterjee","orcid":"0000-0002-7138-4449","position":6,"is_corresponding":false},{"id":827962,"name":"Nagaraja Mukkayyan","orcid":"0000-0002-6767-7732","position":0,"is_corresponding":true}],"reference_count":26,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:33:03.486542Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}