{"doi":"10.1101/2022.05.16.491863","title":"Therapeutic neutralizing monoclonal antibody administration protects against lethal Yellow Fever infection","abstract":"ABSTRACT Few countermeasures to treat Yellow Fever virus (YFV) infection are under development, because vaccines have helped to limit new infections. Unfortunately, vaccine hesitancy, supply deficits, and a paucity of therapeutic options have left individuals at risk. Here, we tested potent YFV-specific neutralizing monoclonal antibodies in rodents and non-human primates. We administered antibodies during acute pathogenic YFV infection and demonstrate that we can prevent severe disease and death. Given the severity of YFV-induced disease, our results show that these antibodies could be effective in saving lives and fill a much-needed void in managing Yellow Fever cases during outbreaks around the world. One Sentence Summary Therapeutic monoclonal antibodies prevent death from YFV infection.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":308631,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9554,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":903183,"name":"Lauren N. Rust","orcid":"0000-0001-8585-466X","position":1,"is_corresponding":false},{"id":279510,"name":"Núria Pedreño-López","orcid":"0000-0001-6927-2301","position":2,"is_corresponding":false},{"id":903185,"name":"Sofiya Yusova","orcid":"0000-0002-4773-9609","position":3,"is_corresponding":false},{"id":502598,"name":"Sreya Biswas","orcid":"0000-0003-4832-5544","position":4,"is_corresponding":false},{"id":259644,"name":"Gabriela M. Webb","orcid":"0000-0001-6084-4166","position":5,"is_corresponding":false},{"id":432419,"name":"Lucas Gonzalez-Nieto","orcid":"0000-0003-1580-3044","position":6,"is_corresponding":false},{"id":302909,"name":"Thomas B. Voigt","orcid":"0000-0003-2217-897X","position":7,"is_corresponding":false},{"id":819017,"name":"Johan J. Louw","orcid":"0000-0002-4887-858X","position":8,"is_corresponding":false},{"id":1003140,"name":"Fernanda D. Laurino","orcid":"0000-0001-7504-1673","position":9,"is_corresponding":false},{"id":1003444,"name":"John R. DiBello","orcid":null,"position":10,"is_corresponding":false},{"id":335554,"name":"Hans-Peter Raué","orcid":null,"position":11,"is_corresponding":false},{"id":389644,"name":"Aaron Barber-Axthelm","orcid":null,"position":12,"is_corresponding":false},{"id":941389,"name":"Samantha Uttke","orcid":"0000-0001-8773-2930","position":13,"is_corresponding":false},{"id":818484,"name":"Lidiane Menezes Souza Raphael","orcid":null,"position":14,"is_corresponding":false},{"id":1003141,"name":"Aaron Yrizarry-Medina","orcid":"0000-0002-2940-7109","position":15,"is_corresponding":false},{"id":527089,"name":"Brandon C. Rosen","orcid":"0000-0002-4943-3494","position":16,"is_corresponding":false},{"id":721693,"name":"Rebecca Agnor","orcid":"0000-0003-1577-8133","position":17,"is_corresponding":false},{"id":314329,"name":"Lina Gao","orcid":"0000-0001-9382-0419","position":18,"is_corresponding":false},{"id":525542,"name":"Caralyn S. Labriola","orcid":"0000-0002-8271-6242","position":19,"is_corresponding":false},{"id":263668,"name":"Michael K. Axthelm","orcid":"0000-0002-1984-5906","position":20,"is_corresponding":false},{"id":344045,"name":"Jeremy Smedley","orcid":"0000-0003-3369-4662","position":21,"is_corresponding":false},{"id":343866,"name":"Justin G. Julander","orcid":"0000-0001-6888-7320","position":22,"is_corresponding":false},{"id":356759,"name":"Myrna C. Bonaldo","orcid":"0000-0001-9899-3386","position":23,"is_corresponding":false},{"id":109550,"name":"Laura M. Walker","orcid":"0000-0001-7704-3197","position":24,"is_corresponding":false},{"id":366007,"name":"Ilhem Messaoudi","orcid":"0000-0003-3203-2405","position":25,"is_corresponding":false},{"id":314328,"name":"Mark K. Slifka","orcid":"0000-0001-8205-6136","position":26,"is_corresponding":false},{"id":108980,"name":"Dennis R. Burton","orcid":"0000-0001-6711-9864","position":27,"is_corresponding":false},{"id":285114,"name":"Esper G. Kallás","orcid":"0000-0003-2026-6925","position":28,"is_corresponding":false},{"id":259654,"name":"Jonah B. Sacha","orcid":"0000-0002-7633-3122","position":29,"is_corresponding":false},{"id":531983,"name":"David I. Watkins","orcid":"0000-0003-2826-9661","position":30,"is_corresponding":false},{"id":385191,"name":"Benjamin J. Burwitz","orcid":"0000-0001-7767-022X","position":31,"is_corresponding":false},{"id":432420,"name":"Michael J. Ricciardi","orcid":"0000-0002-8098-8666","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:33:03.486542Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}