{"doi":"10.1101/2022.05.06.490918","title":"Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells","abstract":"Abstract The essential role of store-operated Ca 2+ entry (SOCE) through Ca 2+ release-activated Ca 2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B cells are poorly understood. Here, we demonstrate changes in expression of Orai isoforms in response to B cell activation. We show that Orai3 and Orai1 are essential components of native CRAC channels in B cells and are critical for primary B cell proliferation and survival. The combined loss of Orai1 and Orai3 strongly impairs SOCE, nuclear factor for activated T cells (NFAT) activation, mitochondrial respiration, glycolysis, and the metabolic reprogramming of B cells in response to antigenic stimulation. Our results clarify the molecular composition and cellular functions of SOCE in B lymphocytes.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":303237,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":262126,"name":"Ryan E. Yoast","orcid":"0000-0002-7059-6829","position":1,"is_corresponding":false},{"id":264986,"name":"Xuexin Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":262129,"name":"Adam J. Fike","orcid":"0000-0002-7105-6162","position":3,"is_corresponding":false},{"id":815116,"name":"Yin‐Hu Wang","orcid":"0000-0002-3637-8852","position":4,"is_corresponding":false},{"id":788943,"name":"Kristen N Bricker","orcid":"0000-0001-8963-9780","position":5,"is_corresponding":false},{"id":882401,"name":"Anthony Tao","orcid":"0000-0003-0978-2769","position":6,"is_corresponding":false},{"id":264987,"name":"Ping Xin","orcid":null,"position":7,"is_corresponding":false},{"id":18211,"name":"Vonn Walter","orcid":"0000-0001-6114-6714","position":8,"is_corresponding":false},{"id":262128,"name":"Martin Johnson","orcid":"0000-0002-4706-8294","position":9,"is_corresponding":false},{"id":656426,"name":"Trayambak Pathak","orcid":"0000-0002-0719-2995","position":10,"is_corresponding":false},{"id":351853,"name":"Adam C. Straub","orcid":"0000-0003-0542-9466","position":11,"is_corresponding":false},{"id":244372,"name":"Stefan Feske","orcid":"0000-0001-5431-8178","position":12,"is_corresponding":false},{"id":413549,"name":"Ziaur S. M. Rahman","orcid":"0000-0001-8431-9681","position":13,"is_corresponding":false},{"id":262132,"name":"Mohamed Trebak","orcid":"0000-0001-6759-864X","position":14,"is_corresponding":false},{"id":262127,"name":"Scott M. Emrich","orcid":"0000-0002-4804-7436","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T00:32:24.307938Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}