{"doi":"10.1101/2022.05.05.490771","title":"Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer","abstract":"ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stroma and often experiences conditions of insufficient oxygen availability, or hypoxia. Cancer-associated fibroblasts (CAF) are a predominant and heterogeneous population of stromal cells within the pancreatic tumor microenvironment. Here, we uncover a previously unrecognized role for hypoxia in driving an inflammatory phenotype in PDAC CAFs. We identify hypoxia as a strong inducer of tumor IL1α expression, which is required for inflammatory CAF (iCAF) formation. Notably, iCAFs preferentially reside in hypoxic regions of PDAC. Our data implicate hypoxia as a critical regulator of CAF heterogeneity in PDAC.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":299189,"datarank":0.36469382011707036,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.12327813325195527,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.12327813325195527,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":461507,"name":"Tenzin Ngodup","orcid":"0000-0002-9034-2957","position":1,"is_corresponding":false},{"id":989016,"name":"Yusoo Lee","orcid":null,"position":2,"is_corresponding":false},{"id":225414,"name":"Katelyn L. Donahue","orcid":"0000-0001-9535-9275","position":3,"is_corresponding":false},{"id":988645,"name":"Jinju Li","orcid":"0009-0001-4269-9150","position":4,"is_corresponding":false},{"id":69715,"name":"Arvind Rao","orcid":"0000-0002-9613-426X","position":5,"is_corresponding":false},{"id":225393,"name":"Eileen S. Carpenter","orcid":"0000-0001-6775-6943","position":6,"is_corresponding":false},{"id":225419,"name":"Howard C. Crawford","orcid":"0000-0001-9360-3019","position":7,"is_corresponding":false},{"id":225422,"name":"Marina Pasca di Magliano","orcid":"0000-0001-9632-9035","position":8,"is_corresponding":false},{"id":988646,"name":"Kyoung Eun Lee","orcid":"0000-0002-3955-7389","position":9,"is_corresponding":false},{"id":988644,"name":"Ashley M. Mello","orcid":"0000-0002-3280-181X","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:40.528568Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}