{"doi":"10.1101/2022.05.02.490277","title":"Helminth egg derivatives as pro-regenerative immunotherapies","abstract":"Abstract The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other type 2-associated cytokines without negative infection-related sequelae. The regenerative SEA (rSEA) applied to a murine muscle injury induced accumulation of IL-4 expressing T helper cells, eosinophils, and regulatory T cells, and decreased expression of IL-17A in gamma delta (γδ) T cells, resulting in improved repair and decreased fibrosis. Encapsulation and controlled release of rSEA in a hydrogel further enhanced type 2 immunity and larger volumes of tissue repair. The broad regenerative capacity of rSEA was validated in articular joint and corneal injury models. These results introduce a new regenerative immunotherapy approach using natural helminth-derivatives. One-Sentence Summary Helminth-derived soluble egg antigen regenerative immunotherapies promote tissue repair in multiple injury models.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":303229,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9574,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":238247,"name":"Liam Chung","orcid":"0000-0002-3919-6253","position":1,"is_corresponding":false},{"id":238243,"name":"Jin Han","orcid":"0000-0001-8799-5140","position":2,"is_corresponding":false},{"id":995471,"name":"Xiaokun Wang","orcid":"0009-0003-8676-9450","position":3,"is_corresponding":false},{"id":995472,"name":"Sven D. Sommerfeld","orcid":"0000-0002-0376-1513","position":4,"is_corresponding":false},{"id":709983,"name":"Erika Moore","orcid":"0000-0003-2192-6147","position":5,"is_corresponding":false},{"id":817710,"name":"Helen Nguyễn","orcid":"0000-0001-8015-5296","position":6,"is_corresponding":false},{"id":817708,"name":"Joscelyn C. Mejías","orcid":"0000-0003-4397-9741","position":7,"is_corresponding":false},{"id":238246,"name":"Alexis N. Peña","orcid":"0000-0003-1899-8625","position":8,"is_corresponding":false},{"id":312597,"name":"Hong Zhang","orcid":"0000-0002-6191-0046","position":9,"is_corresponding":false},{"id":668216,"name":"Joshua S. T. Hooks","orcid":"0000-0003-0557-3409","position":10,"is_corresponding":false},{"id":668217,"name":"Alexander F. Chin","orcid":"0000-0003-0498-2577","position":11,"is_corresponding":false},{"id":556393,"name":"James I. 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Zack","orcid":"0000-0002-7966-1973","position":22,"is_corresponding":false},{"id":62910,"name":"Franck Housseau","orcid":"0000-0002-7028-3953","position":23,"is_corresponding":false},{"id":59439,"name":"Drew M. Pardoll","orcid":"0000-0001-6215-1013","position":24,"is_corresponding":false},{"id":237878,"name":"Jennifer H. Elisseeff","orcid":"0000-0002-5066-1996","position":25,"is_corresponding":false},{"id":238248,"name":"David R. Maestas","orcid":"0000-0002-8207-1835","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T00:32:24.307938Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}