{"doi":"10.1101/2022.05.02.490206","title":"H3AGWAS : A portable workflow for Genome Wide Association Studies","abstract":"Abstract Background Genome-wide association studies (GWAS) are a powerful method to detect associations between variants and phenotypes. A GWAS requires several complex computations with large data sets, and many steps may need to be repeated with varying parameters. Manual running of these analyses can be tedious, error-prone and hard to reproduce. Results The H3AGWAS workflow from the Pan-African Bioinformatics Network for H3Africa is a powerful, scalable and portable workflow implementing pre-association analysis, implementation of various association testing methods and postassociation analysis of results. Conclusions The workflow is scalable — laptop to cluster to cloud (e.g., SLURM, AWS Batch, Azure). All required software is containerised and can run under Docker on Singularity.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":299216,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9338,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":728498,"name":"Lindsay V. Clark","orcid":"0000-0002-3881-9252","position":1,"is_corresponding":false},{"id":231113,"name":"Gerrit Botha","orcid":"0000-0001-7499-3760","position":2,"is_corresponding":false},{"id":91018,"name":"Sumir Panji","orcid":"0000-0003-0447-0598","position":3,"is_corresponding":false},{"id":390039,"name":"Shakuntala Baichoo","orcid":"0000-0002-9335-1939","position":4,"is_corresponding":false},{"id":656691,"name":"Christopher J. Fields","orcid":"0000-0002-7749-5844","position":5,"is_corresponding":false},{"id":231123,"name":"Scott Hazelhurst","orcid":"0000-0002-0581-149X","position":6,"is_corresponding":false},{"id":368794,"name":"Jean‐Tristan Brandenburg","orcid":"0000-0003-0197-2648","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T00:31:44.904250Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}