{"doi":"10.1101/2022.04.22.489206","title":"IL-17A-mediated alterations in gut microbiota composition, particularly changes in Prevotella abundance, impact Treg function in CNS Autoimmunity","abstract":"Abstract A disrupted equilibrium among gut microbiota, IL-17A-producing CD4 T-cells (Th17), and regulatory CD4 T-cells (Treg) have been linked with the pathobiology of multiple sclerosis (MS). While gut microbiota can regulate both Treg and Th17 cells, the impact of IL-17A on this gut-immune connection remains unclear. Utilizing HLA-DR3 transgenic mouse model of MS, we show that IL-17A deficiency (HLA-DR3.IL17A -/- ) resulted in milder disease characterized by increased Tregs and expansion of Treg-promoting gut microbes, including Prevotella . Cohousing HLA-DR3 mice with HLA-DR3.IL17A -/- transferred the milder disease phenotype and associated microbiota changes to DR3 mice, highlighting the dominant role of gut microbiota in Treg induction and disease amelioration. DR3.IL17A -/- mice also showed a higher abundance of functional pathways linked with short-chain fatty acid synthesis and elevated IL-10 in dendritic cells. Enrichment of the Treg-promoting PPAR signaling pathway expression in the colon of HLA-DR3.IL17A -/- mice and following Prevotella administration in HLA-DR3 mice underscores the importance of gut microbiota in IL-17A-mediated immune regulation. Thus, our study uncovers a previously unappreciated role for IL-17A in shaping gut microbiota and immune regulation, with far-reaching implications for MS treatment. One-Sentence Summary IL-17A modulates Treg and gut microbiota to control EAE","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":301266,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9496,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":866239,"name":"Sudeep Ghimire","orcid":"0000-0001-7769-7764","position":1,"is_corresponding":false},{"id":456166,"name":"Samantha N. Jensen","orcid":"0000-0002-3001-5217","position":2,"is_corresponding":false},{"id":866853,"name":"Peter Lehman","orcid":null,"position":3,"is_corresponding":false},{"id":992829,"name":"Allison G Rux","orcid":null,"position":4,"is_corresponding":false},{"id":992830,"name":"Ti-Ara J. Turner","orcid":null,"position":5,"is_corresponding":false},{"id":251348,"name":"Nicholas Borcherding","orcid":"0000-0003-1427-6342","position":6,"is_corresponding":false},{"id":456168,"name":"Katherine N. Gibson‐Corley","orcid":"0000-0002-1846-1580","position":7,"is_corresponding":false},{"id":274560,"name":"Sukirth M. Ganesan","orcid":"0000-0002-6303-7287","position":8,"is_corresponding":false},{"id":384619,"name":"Nitin J. Karandikar","orcid":"0000-0002-6867-6950","position":9,"is_corresponding":false},{"id":340390,"name":"Ashutosh K. Mangalam","orcid":"0000-0002-9926-2531","position":10,"is_corresponding":false},{"id":456165,"name":"Shailesh K. Shahi","orcid":"0000-0002-8506-7655","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T00:32:02.193874Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}