{"doi":"10.1101/2022.04.18.22273967","title":"A boost with SARS-CoV-2 BNT162b2 mRNA vaccine elicits strong humoral responses independently of the interval between the first two doses","abstract":"SUMMARY Due to the recrudescence of SARS-CoV-2 infections worldwide, mainly caused by Omicron BA.1 and BA.2 variants of concern, several jurisdictions are administering a mRNA vaccine boost. Here, we analyzed humoral responses induced after the second and third doses of mRNA vaccine in naïve and previously-infected donors who received their second dose with an extended 16-week interval. We observed that the extended interval elicited robust humoral responses against VOCs, but this response was significantly diminished 4 months after the second dose. Administering a boost to these individuals brought back the humoral responses to the same levels obtained after the extended second dose. Interestingly, we observed that administering a boost to individuals that initially received a short 3-4 weeks regimen elicited humoral responses similar to those elicited in the long interval regimen. Nevertheless, humoral responses elicited by the boost in naïve individuals did not reach those present in previously-infected vaccinated individuals.","journal":"medRxiv","year":2022,"id":297680,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9559,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":443634,"name":"Shang Yu Gong","orcid":"0000-0001-8211-6207","position":1,"is_corresponding":false},{"id":480442,"name":"Mark M. Painter","orcid":"0000-0002-0180-2748","position":2,"is_corresponding":false},{"id":6622,"name":"Rishi Raj Goel","orcid":"0000-0003-1715-5191","position":3,"is_corresponding":false},{"id":846329,"name":"Debashree Chatterjee","orcid":"0000-0003-0276-9262","position":4,"is_corresponding":false},{"id":241565,"name":"Guillaume Beaudoin-Bussières","orcid":"0000-0002-8092-4101","position":5,"is_corresponding":false},{"id":807709,"name":"Lorie Marchitto","orcid":"0000-0002-4367-0229","position":6,"is_corresponding":false},{"id":661720,"name":"Marianne Boutin","orcid":"0000-0001-5443-6692","position":7,"is_corresponding":false},{"id":241568,"name":"Annemarie Laumaea","orcid":"0000-0002-4934-597X","position":8,"is_corresponding":false},{"id":892315,"name":"James Okeny","orcid":null,"position":9,"is_corresponding":false},{"id":241575,"name":"Gabrielle Gendron‐Lepage","orcid":"0000-0002-2671-3872","position":10,"is_corresponding":false},{"id":621586,"name":"Catherine Bourassa","orcid":"0000-0003-1805-8860","position":11,"is_corresponding":false},{"id":243836,"name":"Halima Medjahed","orcid":null,"position":12,"is_corresponding":false},{"id":241570,"name":"Guillaume Goyette","orcid":"0000-0003-3277-568X","position":13,"is_corresponding":false},{"id":614837,"name":"Justine C. Williams","orcid":"0000-0001-8552-6447","position":14,"is_corresponding":false},{"id":805426,"name":"Yuxia Bo","orcid":"0000-0002-0838-4833","position":15,"is_corresponding":false},{"id":624528,"name":"Laurie Gokool","orcid":null,"position":16,"is_corresponding":false},{"id":624529,"name":"Chantal Morrisseau","orcid":null,"position":17,"is_corresponding":false},{"id":624530,"name":"Pascale Arlotto","orcid":null,"position":18,"is_corresponding":false},{"id":241586,"name":"Renée Bazin","orcid":"0000-0001-9594-2532","position":19,"is_corresponding":false},{"id":891665,"name":"Judith Fafard","orcid":"0000-0003-4355-1294","position":20,"is_corresponding":false},{"id":17392,"name":"Cécile Tremblay","orcid":"0000-0002-3440-3436","position":21,"is_corresponding":false},{"id":254288,"name":"Daniel E. Kaufmann","orcid":"0000-0003-4467-136X","position":22,"is_corresponding":false},{"id":623263,"name":"Gaston De Serres","orcid":"0000-0002-1592-5167","position":23,"is_corresponding":false},{"id":241583,"name":"Marceline Côté","orcid":"0000-0002-4664-4325","position":24,"is_corresponding":false},{"id":241567,"name":"Ralf Duerr","orcid":"0000-0001-9569-9237","position":25,"is_corresponding":false},{"id":623265,"name":"Valérie Martel‐Laferrière","orcid":"0000-0001-7973-8582","position":26,"is_corresponding":false},{"id":105450,"name":"Allison R. Greenplate","orcid":"0000-0002-2614-3072","position":27,"is_corresponding":false},{"id":36451,"name":"E. John Wherry","orcid":"0000-0003-0477-1956","position":28,"is_corresponding":false},{"id":241588,"name":"Andrés Finzi","orcid":"0000-0002-4992-5288","position":29,"is_corresponding":false},{"id":621585,"name":"Alexandra Tauzin","orcid":"0000-0001-9153-3600","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T00:31:26.161109Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}