{"doi":"10.1101/2022.04.12.488084","title":"Interpreting the pervasive observation of U-shaped Site Frequency Spectra","abstract":"Abstract The standard neutral model of molecular evolution has traditionally been used as the null model for population genomics. We gathered a collection of 45 genome-wide site frequency spectra from a diverse set of species, most of which display an excess of low and high frequency variants compared to the expectation of the standard neutral model, resulting in U-shaped spectra. We show that multiple merger coalescent models often provide a better fit to these observations than the standard Kingman coalescent. Hence, in many circumstances these under-utilized models may serve as the more appropriate reference for genomic analyses. We further discuss the underlying evolutionary processes that may result in the widespread U-shape of frequency spectra.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":298218,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9447,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":987226,"name":"Élise Kerdoncuff","orcid":"0000-0001-9294-3708","position":1,"is_corresponding":false},{"id":987227,"name":"Sebastian Matuszewski","orcid":"0000-0002-4393-9283","position":2,"is_corresponding":false},{"id":987228,"name":"Marguerite Lapierre","orcid":"0000-0002-3115-5940","position":3,"is_corresponding":false},{"id":987720,"name":"Marcel Hildebrandt","orcid":null,"position":4,"is_corresponding":false},{"id":7661,"name":"Jeffrey D. Jensen","orcid":"0000-0002-4786-8064","position":5,"is_corresponding":false},{"id":209288,"name":"Luca Ferretti","orcid":"0000-0001-7578-7301","position":6,"is_corresponding":false},{"id":502561,"name":"Amaury Lambert","orcid":"0000-0002-7248-9955","position":7,"is_corresponding":false},{"id":19202,"name":"Timothy B. Sackton","orcid":"0000-0003-1673-9216","position":8,"is_corresponding":false},{"id":987229,"name":"Guillaume Achaz","orcid":"0000-0003-4514-5935","position":9,"is_corresponding":false},{"id":987225,"name":"Fabian Freund","orcid":"0000-0002-9958-2703","position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:36.269611Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}