{"doi":"10.1101/2022.04.03.486888","title":"A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives glioblastoma progression","abstract":"Summary Monocytes and monocyte-derived macrophages (MDM) from blood circulation infiltrate and promote glioblastoma growth. Here we discover that glioma cells induce the expression of potent pro-inflammatory cytokine IL-1β in MDM, which engages IL-1R1 in glioma cells, activates NF-κB pathway, and subsequently leads to the induction of monocyte chemoattractant proteins (MCPs). Thus, a feedforward paracrine circuit of IL-1β/IL-1R1 between the tumors and MDM creates an interdependence driving glioblastoma progression. Locally antagonizing IL-1β/IL-1R1 leads to reduced MDM infiltration, diminished tumor growth, reduced exhausted CD8 + T cells, and thereby extends the survival of tumor-bearing mice. In contrast to IL-1β, IL-1a exhibits anti-tumor effects. Genetic deletion of Il1a is associated with decreased recruitment of lymphoid cells and loss of interferon (IFN) signaling in various immune populations and subsets of malignant cells. IL-1β antagonism of IL-1β should be considered as an effective anti-glioblastoma therapy. Graphical Abstract","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":297909,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":38306,"name":"Bruno Giotti","orcid":"0000-0001-8102-5266","position":1,"is_corresponding":false},{"id":448010,"name":"Milota Kaluzová","orcid":null,"position":2,"is_corresponding":false},{"id":305850,"name":"Cameron J. Herting","orcid":"0000-0002-4937-8392","position":3,"is_corresponding":false},{"id":477112,"name":"Gonzalo Piñero","orcid":"0000-0001-8510-9598","position":4,"is_corresponding":false},{"id":986977,"name":"Montse Puigdelloses Vallcorba","orcid":null,"position":5,"is_corresponding":false},{"id":64649,"name":"Simona Cristea","orcid":"0009-0003-1276-186X","position":6,"is_corresponding":false},{"id":986453,"name":"James Ross","orcid":"0000-0002-7311-416X","position":7,"is_corresponding":false},{"id":588577,"name":"James Ackley","orcid":null,"position":8,"is_corresponding":false},{"id":986454,"name":"Victor Maximov","orcid":"0000-0001-5308-1885","position":9,"is_corresponding":false},{"id":305852,"name":"Frank Szulzewsky","orcid":"0000-0001-5710-9590","position":10,"is_corresponding":false},{"id":986978,"name":"Mar Marquez-Ropero","orcid":null,"position":11,"is_corresponding":false},{"id":867350,"name":"Angelo Angione","orcid":"0000-0001-7713-5833","position":12,"is_corresponding":false},{"id":986455,"name":"Noah Nichols","orcid":"0000-0001-9309-1295","position":13,"is_corresponding":false},{"id":2003,"name":"Nadejda M. Tsankova","orcid":"0000-0002-5333-312X","position":14,"is_corresponding":false},{"id":88477,"name":"Franziska Michor","orcid":"0009-0003-8552-7767","position":15,"is_corresponding":false},{"id":290772,"name":"Dmitry M. Shayakhmetov","orcid":"0000-0002-8320-9007","position":16,"is_corresponding":false},{"id":295596,"name":"David H. Gutmann","orcid":"0000-0002-3127-5045","position":17,"is_corresponding":false},{"id":12171,"name":"Alexander M. Tsankov","orcid":"0000-0002-7955-4414","position":18,"is_corresponding":false},{"id":305861,"name":"Dolores Hambardzumyan","orcid":"0000-0003-1975-4665","position":19,"is_corresponding":false},{"id":305849,"name":"Zhihong Chen","orcid":"0000-0001-7403-7015","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:31.270564Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}