{"doi":"10.1101/2022.03.29.486301","title":"Accounting for <i>cis</i> -regulatory constraint prioritizes genes likely to affect species-specific traits","abstract":"Abstract Measuring allele-specific expression in interspecies hybrids is a powerful way to detect cis-regulatory changes underlying adaptation. However, it remains difficult to identify genes most likely to explain species-specific traits. Here, we outline a simple strategy that leverages population-scale allele-specific RNA-seq data to identify genes that have constrained cis - regulation within species yet show divergence between species. Applying this strategy to data from human-chimpanzee hybrid cortical spheroids, we identify signatures of lineage-specific selection on genes related to cellular proliferation, speech, and glucose metabolism. We also highlight cis-regulatory divergence in CUX1 and EDNRB that may shape the unique trajectory of human brain development.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":303000,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":37001,"name":"David Gokhman","orcid":"0000-0002-3536-9006","position":1,"is_corresponding":false},{"id":480859,"name":"Hunter B. Fraser","orcid":"0000-0001-8400-8541","position":2,"is_corresponding":false},{"id":995066,"name":"Alexander L. Starr","orcid":"0000-0001-6297-9742","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:20.348385Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}