{"doi":"10.1101/2022.03.15.484523","title":"<i>Chlamydia trachomatis</i> suppresses host cell store-operated Ca <sup>2+</sup> entry and inhibits NFAT/calcineurin signaling","abstract":"Abstract The obligate intracellular bacterium, Chlamydia trachomatis , replicates within a parasitophorous vacuole termed an inclusion. During development, host proteins critical for regulating intracellular calcium (Ca 2+ ) homeostasis interact with the inclusion membrane. The inclusion membrane protein, MrcA, interacts with the inositol-trisphosphate receptor (IP3R), an ER cationic channel that conducts Ca 2+ . Stromal interaction molecule 1 (STIM1), an ER transmembrane protein important for regulating store-operated Ca 2+ entry (SOCE), localizes to the inclusion membrane via an uncharacterized interaction. We therefore examined Ca 2+ mobilization in C. trachomatis infected cells. Utilizing a variety of Ca 2+ indicators to assess changes in cytosolic Ca 2+ concentration, we demonstrate that C. trachomatis impairs host cell SOCE. Ca 2+ regulates many cellular signaling pathways. We find that the SOCE-dependent NFAT/calcineurin signaling pathway is impaired in C. trachomatis L2 infected HeLa cells and likely has major implications on host cell physiology as it relates to C. trachomatis pathogenesis.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":302844,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9569,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334735,"name":"Ted Hackstadt","orcid":"0000-0003-1367-5528","position":1,"is_corresponding":false},{"id":994984,"name":"Nicholas B. Chamberlain","orcid":"0000-0002-5651-8904","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:20.348385Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}