{"doi":"10.1101/2022.03.09.22271910","title":"Plasma metabolites associated with cognitive function across race/ethnicities affirming the importance of healthy nutrition","abstract":"Abstract INTRODUCTION We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations. METHODS We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n= 2,222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n=1,365) and African (n=478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function. RESULTS Six metabolites were consistently associated with lower global cognitive function across all studies. Of these, four were sugar related (e.g., ribitol). MR analyses provided weak evidence for a potential causal effect of ribitol on cognitive function and bi-directional effects of cognitive performance on diet. DISCUSSION Several diet-related metabolites were associated with global cognitive function across studies with different race/ethnicities.","journal":"medRxiv","year":2022,"id":301019,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9461,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259845,"name":"Shan He","orcid":"0000-0003-2958-9659","position":1,"is_corresponding":false},{"id":270495,"name":"Jan Bressler","orcid":"0000-0001-6578-4772","position":2,"is_corresponding":false},{"id":51217,"name":"Bing Yu","orcid":"0000-0003-4818-1077","position":3,"is_corresponding":false},{"id":303806,"name":"Wassim Tarraf","orcid":"0000-0001-8888-7918","position":4,"is_corresponding":false},{"id":261908,"name":"Casey M. Rebholz","orcid":"0000-0002-5442-8745","position":5,"is_corresponding":false},{"id":577698,"name":"Jianwen Cai","orcid":"0000-0003-1813-0594","position":6,"is_corresponding":false},{"id":37769,"name":"Queenie Chan","orcid":"0000-0001-9278-230X","position":7,"is_corresponding":false},{"id":876530,"name":"Tanya P. Garcia","orcid":"0000-0001-9900-4025","position":8,"is_corresponding":false},{"id":73351,"name":"Thomas H. Mosley","orcid":"0000-0003-3343-1352","position":9,"is_corresponding":false},{"id":75182,"name":"Bruce S. Kristal","orcid":"0000-0001-6103-7745","position":10,"is_corresponding":false},{"id":277082,"name":"Charles DeCarli","orcid":"0000-0003-1914-2693","position":11,"is_corresponding":false},{"id":17640,"name":"Myriam Fornage","orcid":"0000-0003-0677-8158","position":12,"is_corresponding":false},{"id":442318,"name":"Guo‐Chong Chen","orcid":"0000-0003-1853-6244","position":13,"is_corresponding":false},{"id":90132,"name":"Qibin Qi","orcid":"0000-0002-2687-1758","position":14,"is_corresponding":false},{"id":440310,"name":"Robert C. Kaplan","orcid":"0000-0003-3271-801X","position":15,"is_corresponding":false},{"id":303812,"name":"Hector M. González","orcid":"0000-0003-4867-7902","position":16,"is_corresponding":false},{"id":17004,"name":"Tamar Sofer","orcid":"0000-0001-8520-8860","position":17,"is_corresponding":false},{"id":303805,"name":"Einat Granot‐Hershkovitz","orcid":"0000-0003-0645-2713","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:57.812980Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}