{"doi":"10.1101/2022.02.14.480339","title":"Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination","abstract":"<jats:title>Summary</jats:title>\n                <jats:p>\n                  In the developing central nervous system, oligodendrocyte precursor cells (OPCs) differentiate into oligodendrocytes, which form myelin around axons. Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced by the severe neurological symptoms that arise in demyelinating diseases such as multiple sclerosis and leukodystrophy. Although many cell-intrinsic mechanisms that regulate oligodendrocyte development and myelination have been reported, it remains unclear whether interactions among oligodendrocyte-lineage cells (OPCs and oligodendrocytes) affect oligodendrocyte development and myelination. Here, we show that blocking vesicle-associated membrane protein (VAMP) 1/2/3-dependent exocytosis from oligodendrocyte-lineage cells impairs oligodendrocyte development, myelination, and motor behavior in mice. Adding oligodendrocyte-lineage cell-secreted molecules to secretion-deficient OPC cultures partially restores the morphological maturation of oligodendrocytes. Moreover, we identified L-type prostaglandin D synthase as an oligodendrocyte-lineage cell-secreted protein that promotes oligodendrocyte development and myelination\n                  <jats:italic>in vivo</jats:italic>\n                  . These findings reveal a novel autocrine/paracrine loop model for the regulation of oligodendrocyte and myelin development.\n                </jats:p>","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":null,"id":44935,"datarank":0.3468909824090658,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.10547529554395074,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.10547529554395074,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":210661,"name":"Amelia Trimarco","orcid":null,"position":1,"is_corresponding":false},{"id":210662,"name":"Alice J. Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":210663,"name":"Ko Fujimori","orcid":null,"position":3,"is_corresponding":false},{"id":210664,"name":"Yoshihiro Urade","orcid":null,"position":4,"is_corresponding":false},{"id":210665,"name":"Lu O. Sun","orcid":null,"position":5,"is_corresponding":false},{"id":210666,"name":"Carla Taveggia","orcid":"0000-0002-6531-9544","position":6,"is_corresponding":false},{"id":340,"name":"Ye Zhang","orcid":"0009-0000-4883-8097","position":7,"is_corresponding":false},{"id":210660,"name":"Lin Pan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36779701","pmcid":null,"openalex_id":"https://openalex.org/W4212913701","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"5P50HD103557-02","title":"UCLA IDDRC"},{"funder_name":"National Institutes of Health","grant_id":"5R01NS109025-05","title":"Molecular characterization of reactive astrocytes in humans"},{"funder_name":"National Institutes of Health","grant_id":"5R00NS089780-04","title":"Identification of transcription factors that regulate astrocyte differentiation"},{"funder_name":"National Institutes of Health","grant_id":"5R01NS099102-02","title":"MOLECULAR MECHANISMS CONTROLLING PNS MYELIN MAINTENANCE"},{"funder_name":"National Institutes of Health","grant_id":"5R03AG065772-02","title":"Identification of candidate juvenile protective factors in neuron, glia, and vascular cells of human and mouse brain"},{"funder_name":"National Institutes of Health","grant_id":"3UL1TR001881-01S2","title":"UCLA Clinical Translational Science Institute"}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":1}],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://www.biorxiv.org/content/biorxiv/early/2022/02/14/2022.02.14.480339.full.pdf","host_type":"repository"},{"url":"https://doi.org/10.1101/2022.02.14.480339","host_type":"GREEN"},{"url":"https://www.biorxiv.org/content/biorxiv/early/2022/02/14/2022.02.14.480339.full.pdf","host_type":"repository"},{"url":"https://syndication.highwire.org/content/doi/10.1101/2022.02.14.480339","host_type":"publisher"},{"url":"https://doi.org/10.7554/elife.77441","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/36779701","host_type":""},{"url":"http://dx.doi.org/10.7554/eLife.77441","host_type":""},{"url":"https://doaj.org/article/8adbcb1ecf924139b56a96be47350b1c","host_type":""}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Nerve injury and regeneration","Neuroinflammation and Neurodegeneration Mechanisms","Medicine","Biology","0301 basic medicine","03 medical and health sciences","0303 health sciences"],"mesh_terms":[],"keywords":["Oligodendrocyte","Myelin","Biology","Cell biology","Neuroscience","Myelin basic protein","Exocytosis","Central nervous system","Secretion","Endocrinology","QH301-705.5","Science","Neurogenesis","oligodendrocytes","oligodendrocyte precursor cells","Mice","Animals","Biology (General)","development","Myelin Sheath","Q","R","Cell Differentiation","L-type prostaglandin D synthase","Lipocalins","Intramolecular Oxidoreductases","Oligodendroglia","Medicine","Developmental Biology"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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