{"doi":"10.1101/2022.02.09.479763","title":"CD36 homologs determine microbial resistance to the Lyme disease spirochete","abstract":"Abstract Pattern recognition receptors sense pathogens in arthropods and mammals through distinct immune processes. Whether these molecules share a similar function and recognize the same microbe in evolutionarily distant species remain ill-defined. Here, we establish that the CD36 superfamily is required for Borrelia burgdorferi resistance in both the arthropod vector and humans. Using the blacklegged tick Ixodes scapularis and an electronic health record-linked biobank, we demonstrate that CD36 members elicit immunity to the Lyme disease spirochete. In ticks, the CD36-like protein Croquemort recognizes lipids and initiates the immune deficiency and jun N-terminal kinase pathways against B. burgdorferi . In humans, exome sequencing and clinical information reveal that individuals with CD36 loss-of-function variants have increased prevalence of Lyme disease. Altogether, we discovered a conserved mechanism of anti-bacterial immunity. One Sentence Summary Lipid receptors belonging to the CD36 superfamily exhibit a shared immune function in both ticks and humans.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":305883,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":757573,"name":"Nisha Singh","orcid":"0000-0003-4897-8123","position":1,"is_corresponding":false},{"id":58023,"name":"Iain S. Forrest","orcid":"0000-0002-5642-422X","position":2,"is_corresponding":false},{"id":300899,"name":"Agustín Rolandelli","orcid":"0000-0003-1059-3578","position":3,"is_corresponding":false},{"id":999926,"name":"Xiaowei Wang","orcid":"0000-0002-9427-3477","position":4,"is_corresponding":false},{"id":548599,"name":"Dana K. Shaw","orcid":"0000-0002-5212-2494","position":5,"is_corresponding":false},{"id":759761,"name":"Brianna D. Young","orcid":"0000-0002-7742-8860","position":6,"is_corresponding":false},{"id":245048,"name":"Sukanya Narasimhan","orcid":"0000-0003-0396-8757","position":7,"is_corresponding":false},{"id":926573,"name":"Shraboni Dutta","orcid":"0000-0002-8000-8111","position":8,"is_corresponding":false},{"id":356051,"name":"Greg A. Snyder","orcid":"0000-0002-4409-0453","position":9,"is_corresponding":false},{"id":318026,"name":"Liron Marnin","orcid":"0009-0004-6398-661X","position":10,"is_corresponding":false},{"id":300898,"name":"L. Rainer Butler","orcid":"0000-0001-8831-1230","position":11,"is_corresponding":false},{"id":363399,"name":"Sourabh Samaddar","orcid":"0000-0003-0746-3924","position":12,"is_corresponding":false},{"id":623566,"name":"Maria Tays Mendes","orcid":"0000-0002-9508-9372","position":13,"is_corresponding":false},{"id":1000182,"name":"Francy E. Cabrera Paz","orcid":null,"position":14,"is_corresponding":false},{"id":1000183,"name":"Luisa M. Valencia","orcid":null,"position":15,"is_corresponding":false},{"id":356052,"name":"Eric J. Sundberg","orcid":"0000-0003-0478-3033","position":16,"is_corresponding":false},{"id":245049,"name":"Erol Fikrig","orcid":"0000-0002-5884-6047","position":17,"is_corresponding":false},{"id":245047,"name":"Utpal Pal","orcid":"0000-0002-7504-4628","position":18,"is_corresponding":false},{"id":379328,"name":"David J. Weber","orcid":"0000-0002-8824-1110","position":19,"is_corresponding":false},{"id":23900,"name":"Ron Do","orcid":"0000-0002-3144-3627","position":20,"is_corresponding":false},{"id":245046,"name":"Joao H. F. Pedra","orcid":"0000-0001-8740-2667","position":21,"is_corresponding":false},{"id":300897,"name":"Anya J. O’Neal","orcid":"0000-0001-5188-1344","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T00:32:44.983506Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}