{"doi":"10.1101/2022.02.05.479270","title":"Genesis of bursting activity: Role of inhibitory constraints on persistent Na <sup>+</sup> currents","abstract":"SUMMARY Some neurons express a plateau of spike activity greatly outlasting a stimulus, whereas others do not. This difference could be due to differential expression of ion channels (e.g., persistent Na + , and Ca 2+ ) or similar expression of channels that differ in their properties. We compared three Aplysia neurons with varying capacity to generate plateau potentials: B51 with self-terminating plateaus, B64 with plateau potentials that do not self-terminate, and the regular spiking neuron B8. Our results indicate the three neurons expressed outward currents I A and I D , voltage-gated Ca 2+ currents I CaL and I CaR , and persistent inward I NaP . The most notable difference observed was a larger I A , I D , and I KCa currents in B8, and the plateau generating B64 did not express I KCa . Computational models suggest outward currents suppress and temporally constrain the plateau potential and that inward Ca 2+ currents suppress plateau potentials when coupled with I KCa .","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":305851,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":546464,"name":"Douglas A. Baxter","orcid":null,"position":1,"is_corresponding":false},{"id":498982,"name":"John H. Byrne","orcid":"0000-0001-7947-5890","position":2,"is_corresponding":false},{"id":801128,"name":"Curtis L. Neveu","orcid":"0000-0003-3291-7537","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-19T00:32:44.983506Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}