{"doi":"10.1101/2022.02.03.479007","title":"VE607 Stabilizes SARS-CoV-2 Spike In the “RBD-up” Conformation and Inhibits Viral Entry","abstract":"Summary SARS-CoV-2 infection of host cells starts by binding of the Spike glycoprotein (S) to the ACE2 receptor. The S-ACE2 interaction is a potential target for therapies against COVID-19 as demonstrated by the development of immunotherapies blocking this interaction. Here, we present the commercially available VE607, comprised of three stereoisomers, that was originally described as an inhibitor of SARS-CoV-1. We show that VE607 specifically inhibits infection of SARS-CoV-1 and SARS-CoV-2 S-expressing pseudoviral particles as well as authentic SARS-CoV-2. VE607 stabilizes the receptor binding domain (RBD) in its “up” conformation. In silico docking and mutational analysis map the VE607 binding site at the RBD-ACE2 interface. The IC 50 values are in the low micromolar range for pseudoparticles derived from SARS-CoV-2 Wuhan/D614G as well as from variants of concern (Alpha, Beta, Gamma, Delta and Omicron), suggesting that VE607 has potential for the development of drugs against SARS-CoV-2 infections.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":302582,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":443634,"name":"Shang Yu Gong","orcid":"0000-0001-8211-6207","position":1,"is_corresponding":false},{"id":241929,"name":"Jonathan R. Grover","orcid":"0000-0003-2137-600X","position":2,"is_corresponding":false},{"id":357548,"name":"Mohammadjavad Mohammadi","orcid":null,"position":3,"is_corresponding":false},{"id":467518,"name":"Yaozong Chen","orcid":"0000-0001-5380-2339","position":4,"is_corresponding":false},{"id":443633,"name":"Dani Vézina","orcid":"0000-0002-0780-8593","position":5,"is_corresponding":false},{"id":241565,"name":"Guillaume Beaudoin-Bussières","orcid":"0000-0002-8092-4101","position":6,"is_corresponding":false},{"id":908568,"name":"Vijay Tailor Verma","orcid":null,"position":7,"is_corresponding":false},{"id":241570,"name":"Guillaume Goyette","orcid":"0000-0003-3277-568X","position":8,"is_corresponding":false},{"id":241566,"name":"Jonathan Richard","orcid":"0000-0002-9015-9589","position":9,"is_corresponding":false},{"id":908031,"name":"Derek Yang","orcid":"0000-0001-8959-384X","position":10,"is_corresponding":false},{"id":350337,"name":"Amos B. Smith","orcid":"0000-0002-1712-8567","position":11,"is_corresponding":false},{"id":335148,"name":"Marzena Pazgier","orcid":"0000-0003-0594-5057","position":12,"is_corresponding":false},{"id":241583,"name":"Marceline Côté","orcid":"0000-0002-4664-4325","position":13,"is_corresponding":false},{"id":350336,"name":"Cameron F. Abrams","orcid":"0000-0002-1240-0816","position":14,"is_corresponding":false},{"id":241931,"name":"Walther Mothes","orcid":"0000-0002-3367-7240","position":15,"is_corresponding":false},{"id":241588,"name":"Andrés Finzi","orcid":"0000-0002-4992-5288","position":16,"is_corresponding":false},{"id":908032,"name":"Christian Baron","orcid":"0000-0002-0132-2111","position":17,"is_corresponding":false},{"id":241572,"name":"Shilei Ding","orcid":"0000-0003-1895-5131","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T00:32:16.279991Z","pmid":"35233570","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}