{"doi":"10.1101/2022.01.31.22270028","title":"Cost effective sequencing enables longitudinal profiling of clonal hematopoiesis","abstract":"ABSTRACT Clonal hematopoiesis of indeterminate potential (CHIP), the age-related expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging including hematologic cancer and cardiovascular disease. Whole-exome or genome sequencing can detect CHIP, but due to its high cost, most population studies have been cross-sectional, sequencing only a single timepoint. Here we describe a cost-effective sequencing assay for detecting CHIP. We validate this technology on a set of 548 longitudinal and multi-timepoint samples from 182 participants in the Women’s Health Initiative cohort over median 16 years, including 85 participants with ≥3 timepoints assayed. The majority (52.1%) of clonal mutations expanded over time (with a median doubling period of 7.43 years), with the others remaining static or decreasing in size in the absence of any cytotoxic therapy. This assay provides a cost-effective and sensitive platform for investigating the associations between CHIP dynamics and health outcomes at a biobank scale.","journal":"medRxiv","year":2022,"id":302560,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9497,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":14882,"name":"Ying Zhou","orcid":"0000-0002-8107-3927","position":1,"is_corresponding":false},{"id":27378,"name":"Alexander G. Bick","orcid":"0000-0001-5824-9595","position":2,"is_corresponding":false},{"id":218530,"name":"Bala Bharathi Burugula","orcid":"0000-0003-1114-6964","position":3,"is_corresponding":false},{"id":994841,"name":"Sidd Jaiswal","orcid":null,"position":4,"is_corresponding":false},{"id":581705,"name":"Pinkal Desai","orcid":"0000-0002-9816-7284","position":5,"is_corresponding":false},{"id":517704,"name":"Shelly‐Ann Love","orcid":"0000-0001-7643-9798","position":6,"is_corresponding":false},{"id":994842,"name":"Kate Hayden","orcid":null,"position":7,"is_corresponding":false},{"id":11268,"name":"JoAnn E. Manson","orcid":"0000-0002-9426-7595","position":8,"is_corresponding":false},{"id":218550,"name":"Eric A. Whitsel","orcid":"0000-0003-4843-3641","position":9,"is_corresponding":false},{"id":11363,"name":"Charles Kooperberg","orcid":"0000-0002-7986-8560","position":10,"is_corresponding":false},{"id":24665,"name":"Pradeep Natarajan","orcid":"0000-0001-8402-7435","position":11,"is_corresponding":false},{"id":25010,"name":"Alex P. Reiner","orcid":"0000-0002-1427-4470","position":12,"is_corresponding":false},{"id":40413,"name":"Jacob O. Kitzman","orcid":"0000-0002-6145-882X","position":13,"is_corresponding":false},{"id":561964,"name":"Md Mesbah Uddin","orcid":"0000-0003-1846-0411","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:32:16.279991Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}