{"doi":"10.1101/2022.01.26.477844","title":"Epidermal clock integration and gating of brain signals guarantees skin homeostasis","abstract":"Abstract In mammals, an integrated network of molecular oscillators drives daily rhythms of tissue-specific homeostatic processes. This circadian clock network is required for maintaining health and is compromised by disease and lifestyle choices, such as diet and exercise. However, critical properties of this systemic network, such as which tissues communicate to coordinate their respective programs of daily physiology, and the exact homeostatic processes requiring each communication pathway, remain undefined. To dissect daily inter-tissue communication, we have constructed in mice a minimal clock network comprising only two nodes: the peripheral epidermal clock and the central brain clock. By circadian transcriptomic and functional characterization of this isolated connection, we have identified a previously unknown gatekeeping function of the peripheral tissue clock with respect to systemic inputs. That is, the epidermal clock concurrently integrates and corrects brain signals to ensure timely execution of epidermal daily physiology. Specifying the integrative arm of the clock, we identify that timely cell cycle termination in the epidermal stem cell compartment is dependent upon incorporation of clock-driven signals originating from the brain. Unexpectedly, and in contrast, the epidermal clock corrects potentially disruptive feeding-related signals to ensure that DNA replication occurs at the optimum time of day. Together, we present a novel approach for cataloguing the systemic dependencies of a given tissue, and in turn identify an essential gate-keeping function of peripheral circadian clocks that guarantees tissue homeostasis.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":302632,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9408,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":630745,"name":"Valentina M. Zinna","orcid":"0000-0002-1693-5914","position":1,"is_corresponding":false},{"id":994866,"name":"Muge Atalay","orcid":null,"position":2,"is_corresponding":false},{"id":994561,"name":"Carmelo Laudanna","orcid":"0000-0002-0397-6020","position":3,"is_corresponding":false},{"id":630753,"name":"Oleg Deryagin","orcid":"0000-0003-0903-7785","position":4,"is_corresponding":false},{"id":630741,"name":"Jacob G. Smith","orcid":"0000-0001-5139-1054","position":5,"is_corresponding":false},{"id":994562,"name":"Elisa García-Lara","orcid":"0000-0002-3365-0953","position":6,"is_corresponding":false},{"id":630752,"name":"Mireia Vaca-Dempere","orcid":"0000-0002-9804-2924","position":7,"is_corresponding":false},{"id":288783,"name":"Kevin B. Koronowski","orcid":"0000-0002-6808-1789","position":8,"is_corresponding":false},{"id":630750,"name":"Paul Petrus","orcid":"0000-0001-8297-3874","position":9,"is_corresponding":false},{"id":288779,"name":"Carolina M. Greco","orcid":"0000-0002-9895-5635","position":10,"is_corresponding":false},{"id":994867,"name":"Stephen Forrow","orcid":null,"position":11,"is_corresponding":false},{"id":288790,"name":"Paolo Sassone‐Corsi","orcid":"0000-0001-7091-3954","position":12,"is_corresponding":false},{"id":630744,"name":"Patrick-Simon Welz","orcid":"0000-0001-8370-625X","position":13,"is_corresponding":false},{"id":257930,"name":"Pura Muñoz‐Cánoves","orcid":"0000-0002-7533-9047","position":14,"is_corresponding":false},{"id":630757,"name":"Salvador Aznar Benitah","orcid":"0000-0002-9059-5049","position":15,"is_corresponding":false},{"id":630746,"name":"Thomas Mortimer","orcid":"0000-0002-7822-4093","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:32:16.279991Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}