{"doi":"10.1101/2022.01.24.477514","title":"The central clock suffices to drive the majority of circulatory metabolic rhythms","abstract":"Summary Life on Earth anticipates recurring 24-h environmental cycles via genetically-encoded molecular clocks active in all mammalian organs. Communication between these clocks is believed to control circadian homeostasis. Metabolism can be considered a form of inter- tissue communication language that results in temporal coordination of systemic metabolism between tissues. Here we characterize the extent to which clocks in different organs employ this means of communication, an area which remains largely unexplored. For this, we analysed the metabolome of serum from mice with tissue-specific expression of the clock gene Bmal1 . Notably, having functional hepatic and muscle clocks can only drive a minority (13%) of the oscillating metabolites in circulation. Conversely, limiting Bmal1 expression to Syt10 - expressing neurons (which are enriched in the suprachiasmatic nucleus [SCN], the master pacemaker that regulates circadian rhythms) restores rhythms to 57% of circulatory metabolites and 28% of liver transcripts, and rescues glucose intolerance. Importantly, these parameters were also restored in clock-less mice upon rhythmic feeding, indicating that the central clock mainly regulates metabolic rhythms via behavior. These findings explicate the circadian communication between tissues and highlight the importance of the central clock in governing those signals.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":298511,"datarank":0.32492862652950616,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.056164706145297914,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.056164706145297914,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":3,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9514,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":630741,"name":"Jacob G. Smith","orcid":"0000-0001-5139-1054","position":1,"is_corresponding":false},{"id":288783,"name":"Kevin B. Koronowski","orcid":"0000-0002-6808-1789","position":2,"is_corresponding":false},{"id":397037,"name":"Siwei Chen","orcid":"0000-0003-1244-834X","position":3,"is_corresponding":false},{"id":630749,"name":"Tomoki Sato","orcid":"0000-0003-3044-6874","position":4,"is_corresponding":false},{"id":288779,"name":"Carolina M. Greco","orcid":"0000-0002-9895-5635","position":5,"is_corresponding":false},{"id":630746,"name":"Thomas Mortimer","orcid":"0000-0002-7822-4093","position":6,"is_corresponding":false},{"id":630744,"name":"Patrick-Simon Welz","orcid":"0000-0001-8370-625X","position":7,"is_corresponding":false},{"id":630745,"name":"Valentina M. Zinna","orcid":"0000-0002-1693-5914","position":8,"is_corresponding":false},{"id":630748,"name":"Kouhei Shimaji","orcid":"0000-0002-8121-7257","position":9,"is_corresponding":false},{"id":288780,"name":"Marlene Cervantes","orcid":"0000-0003-4619-6144","position":10,"is_corresponding":false},{"id":260113,"name":"Pierre Baldi","orcid":"0000-0001-8752-4664","position":11,"is_corresponding":false},{"id":257930,"name":"Pura Muñoz‐Cánoves","orcid":"0000-0002-7533-9047","position":12,"is_corresponding":false},{"id":288790,"name":"Paolo Sassone‐Corsi","orcid":"0000-0001-7091-3954","position":13,"is_corresponding":false},{"id":630757,"name":"Salvador Aznar Benitah","orcid":"0000-0002-9059-5049","position":14,"is_corresponding":false},{"id":630750,"name":"Paul Petrus","orcid":"0000-0001-8297-3874","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:31:36.269611Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}