{"doi":"10.1101/2022.01.15.476462","title":"The coupling between healthspan and lifespan in <i>Caenorhabditis</i> depends on complex interactions between compound intervention and genetic background","abstract":"Abstract Aging is characterized by declining health that results in decreased neuromuscular function and cellular resilience. The relationship between lifespan and health, and the influence of genetic background on that relationship, has important implications in the development of anti-aging interventions. Here we combined survival under thermal and oxidative stress with swimming performance, to evaluate health effects across a nematode genetic diversity panel for three compounds previously studied in the Caenorhabditis Intervention Testing Program – NP1, propyl gallate, and resveratrol. We show that oxidative stress resistance and thermotolerance vary with compound intervention, genetic background, and age. The effects of tested compounds on swimming locomotion, in contrast, are largely species-specific. Additionally, thermotolerance, but not oxidative stress or swimming ability, correlates with lifespan. Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible aging interventions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":299725,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":823158,"name":"E. Grace Jackson","orcid":null,"position":1,"is_corresponding":false},{"id":424637,"name":"Christine A. Sedore","orcid":"0000-0002-9512-2806","position":2,"is_corresponding":false},{"id":503465,"name":"Brian Onken","orcid":"0000-0001-8818-4497","position":3,"is_corresponding":false},{"id":822639,"name":"David Hall","orcid":"0000-0001-8152-2713","position":4,"is_corresponding":false},{"id":424639,"name":"Anna L Coleman-Hulbert","orcid":"0000-0001-8090-551X","position":5,"is_corresponding":false},{"id":823159,"name":"Phu Huynh","orcid":null,"position":6,"is_corresponding":false},{"id":448285,"name":"Theo Garrett","orcid":null,"position":7,"is_corresponding":false},{"id":424640,"name":"Erik Johnson","orcid":"0000-0003-4041-7866","position":8,"is_corresponding":false},{"id":823164,"name":"Girish Harinath","orcid":null,"position":9,"is_corresponding":false},{"id":823161,"name":"Delaney Inman","orcid":null,"position":10,"is_corresponding":false},{"id":823160,"name":"Suzhen Guo","orcid":null,"position":11,"is_corresponding":false},{"id":447265,"name":"Mackenzie Morshead","orcid":"0000-0003-1023-2350","position":12,"is_corresponding":false},{"id":822640,"name":"Jian Xue","orcid":"0000-0001-6575-2295","position":13,"is_corresponding":false},{"id":425455,"name":"Ron Falkowski","orcid":null,"position":14,"is_corresponding":false},{"id":823162,"name":"Esteban Chen","orcid":null,"position":15,"is_corresponding":false},{"id":990400,"name":"Christopher Herrera","orcid":null,"position":16,"is_corresponding":false},{"id":990401,"name":"Allie J. Kirsch","orcid":null,"position":17,"is_corresponding":false},{"id":524780,"name":"Viviana Pérez","orcid":null,"position":18,"is_corresponding":false},{"id":425456,"name":"Max Guo","orcid":null,"position":19,"is_corresponding":false},{"id":228996,"name":"Gordon J. Lithgow","orcid":"0000-0002-8953-3043","position":20,"is_corresponding":false},{"id":344124,"name":"Monica Driscoll","orcid":"0000-0002-8751-7429","position":21,"is_corresponding":false},{"id":352930,"name":"Patrick C. Phillips","orcid":"0000-0001-7271-342X","position":22,"is_corresponding":false},{"id":424633,"name":"Stephen A. Banse","orcid":"0000-0002-5540-4526","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T00:31:49.412501Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}