{"doi":"10.1101/2022.01.12.476126","title":"Rat Leukocyte Population Dynamics Predicts a Window for Intervention in Aging","abstract":"Abstract Age-associated changes in human hematopoiesis have been mostly recapitulated in mouse models; but not much has been explored in rats, a physiologically closer model to humans. To establish whether rat hematopoiesis closely mirrors humans’, we examined the peripheral blood of rats throughout their lifespan. Significant age-associated changes showed distinctive population shifts predictive of age. A divergence between predicted versus chronological age changes was indicative of fragility; thus, these data may be a valuable tool to identify underlying diseases or as a surrogate predictor for intervention efficacy. Notably, several blood parameters and DNA methylation alterations defined specific leverage points during aging, supporting non-linear aging effects and highlighting a roadmap for interventions at these junctures. Overall, we present a simple set of rat blood metrics that can provide a window into their health and inform the implementation of interventions in a model system physiologically relevant for humans.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2022,"id":305745,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9468,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":323574,"name":"Christopher Dunn","orcid":"0000-0001-7899-0110","position":1,"is_corresponding":false},{"id":68358,"name":"Bongsoo Park","orcid":"0000-0003-1720-9567","position":2,"is_corresponding":false},{"id":287464,"name":"Christopher Coletta","orcid":null,"position":3,"is_corresponding":false},{"id":323570,"name":"Ross A. McDevitt","orcid":"0000-0003-3722-9047","position":4,"is_corresponding":false},{"id":967459,"name":"Taylor McNeely","orcid":"0000-0001-7070-7384","position":5,"is_corresponding":false},{"id":999861,"name":"Michael Leone","orcid":"0000-0001-6976-8868","position":6,"is_corresponding":false},{"id":654117,"name":"Robert P. Wersto","orcid":null,"position":7,"is_corresponding":false},{"id":324765,"name":"Kathy A Perdue","orcid":null,"position":8,"is_corresponding":false},{"id":451525,"name":"Isabel Beerman","orcid":"0000-0002-7758-8231","position":9,"is_corresponding":false},{"id":451524,"name":"Hagai Yanai","orcid":"0000-0003-1742-5411","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-19T00:32:44.983506Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}