{"doi":"10.1101/2021.12.28.474325","title":"Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response","abstract":"ABSTRACT SARS-CoV-2 specific T-cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS-CoV-2 specific T-cell response with antibody levels in these three scenarios is needed. In the present study we found that, in acute infection, while mild disease was associated with high T-cell polyfunctionality biased to IL-2 production and inversely correlated with anti-S IgG levels, combinations only including IFN-γ with absence of perforin production predominated in severe disease. Seven months after infection, both non-hospitalized and previously hospitalized patients presented robust anti-S IgG levels and SARS-CoV-2 specific T-cell response. In addition, only previously hospitalized patients showed a T-cell exhaustion profile. Finally, combinations including IL-2 in response to S protein of endemic coronaviruses, were the ones associated with SARS-CoV-2 S-specific T-cell response in pre-COVID-19 healthy donors’ samples. These results have implications for protective immunity against SARS-CoV-2 and recurrent COVID-19 and may help for the design of new prototypes and boosting vaccine strategies.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":219752,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":819419,"name":"M Carmen Gasca-Capote","orcid":null,"position":1,"is_corresponding":false},{"id":818960,"name":"Joana Vitallé","orcid":"0000-0002-5292-1851","position":2,"is_corresponding":false},{"id":818961,"name":"Francisco José Ostos","orcid":"0000-0001-6583-6974","position":3,"is_corresponding":false},{"id":818962,"name":"Ana Serna‐Gallego","orcid":"0000-0002-7142-0315","position":4,"is_corresponding":false},{"id":818963,"name":"María Trujillo‐Rodríguez","orcid":"0000-0002-4716-4294","position":5,"is_corresponding":false},{"id":818964,"name":"Esperanza Muñoz‐Muela","orcid":"0000-0002-5432-986X","position":6,"is_corresponding":false},{"id":819420,"name":"Teresa Giráldez‐Pérez","orcid":null,"position":7,"is_corresponding":false},{"id":819421,"name":"Julia Praena‐Segovia","orcid":null,"position":8,"is_corresponding":false},{"id":819422,"name":"María Dolores Navarro-Amuedo","orcid":null,"position":9,"is_corresponding":false},{"id":818965,"name":"María Paniagua‐García","orcid":"0000-0003-3156-7512","position":10,"is_corresponding":false},{"id":819423,"name":"Manuel García‐Gutiérrez","orcid":null,"position":11,"is_corresponding":false},{"id":818966,"name":"Manuela Aguilar‐Guisado","orcid":"0000-0001-5639-9434","position":12,"is_corresponding":false},{"id":819424,"name":"Inmaculada Rivas‐Jeremías","orcid":null,"position":13,"is_corresponding":false},{"id":818967,"name":"María Reyes Jiménez‐León","orcid":"0000-0003-2723-319X","position":14,"is_corresponding":false},{"id":818968,"name":"Sara Bachiller","orcid":"0000-0002-9000-3787","position":15,"is_corresponding":false},{"id":819425,"name":"Alberto Fernández‐Villar","orcid":null,"position":16,"is_corresponding":false},{"id":400475,"name":"Alexandre Pérez‐González","orcid":"0000-0003-4836-6768","position":17,"is_corresponding":false},{"id":818969,"name":"Alicia Gutiérrez‐Valencia","orcid":"0000-0003-3445-1574","position":18,"is_corresponding":false},{"id":818970,"name":"Mohammed Rafii‐El‐Idrissi Benhnia","orcid":"0000-0001-7405-9476","position":19,"is_corresponding":false},{"id":103766,"name":"Daniela Weiskopf","orcid":"0000-0003-2968-7371","position":20,"is_corresponding":false},{"id":55670,"name":"Alessandro Sette","orcid":"0000-0001-7013-2250","position":21,"is_corresponding":false},{"id":818971,"name":"Luís F. 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