{"doi":"10.1101/2021.12.22.473909","title":"Structure of anchorless RML prion reveals motif variation between strains","abstract":"Little is known about the structural basis of prion strains. Here we provide a high (3.0 Å) resolution cryo-electron microscopy-based structure of brain-derived fibrils of the mouse anchorless RML scrapie strain which, like the recently determined hamster 263K strain, has a parallel in-register β-sheet-based core. However, detailed comparisons reveal that variations in shared structural motifs provide a basis for prion strain determination. One-sentence summary Cryo-electron microscopy reveals a near-atomic structure of an infectious, brain-derived murine prion fibril and strain differences.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":214457,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9286,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":807933,"name":"Heidi G. Standke","orcid":"0000-0002-5148-9024","position":1,"is_corresponding":false},{"id":804937,"name":"Efrosini Artikis","orcid":null,"position":2,"is_corresponding":false},{"id":662283,"name":"Cindi L. Schwartz","orcid":"0000-0002-0490-6040","position":3,"is_corresponding":false},{"id":804936,"name":"Bryan Hansen","orcid":null,"position":4,"is_corresponding":false},{"id":342601,"name":"Kunpeng Li","orcid":"0000-0003-1807-4545","position":5,"is_corresponding":false},{"id":227556,"name":"Andrew G. Hughson","orcid":"0000-0002-0725-4017","position":6,"is_corresponding":false},{"id":482667,"name":"Matteo Manca","orcid":"0000-0001-5178-0957","position":7,"is_corresponding":false},{"id":807934,"name":"Olivia R. Thomas","orcid":"0009-0002-3846-7549","position":8,"is_corresponding":false},{"id":808499,"name":"Gregory J. Raymond","orcid":null,"position":9,"is_corresponding":false},{"id":807935,"name":"Gerald S. Baron","orcid":"0000-0001-8165-2155","position":10,"is_corresponding":false},{"id":227561,"name":"Byron Caughey","orcid":"0000-0002-3928-6101","position":11,"is_corresponding":false},{"id":268828,"name":"Allison Kraus","orcid":"0000-0001-8477-0894","position":12,"is_corresponding":false},{"id":804342,"name":"Forrest Hoyt","orcid":"0000-0001-9020-6309","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":null,"created_at":"2026-07-18T23:52:46.604690Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}