{"doi":"10.1101/2021.12.20.21267972","title":"Specific methylation marks in promoter regions are associated to the pathogenic process of Chronic Chagas disease Cardiomyopathy by modifying transcription factor binding patterns","abstract":"Abstract Chagas disease, caused by Trypanosoma cruzi , is an endemic parasitical disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, including Chronic Chagasic Cardiomyopathy (CCC), which ranges from moderate to severe stages depending on the cardiac ejection fraction. The pathogenic process remains poorly understood, although genetic and epigenetic factors have already been proposed. Based on bulk RNA-seq and EPIC methylation data, we investigated the genetic and epigenetic deregulations present in the moderate and severe stages of CCC. We identified 4 main biological processes associated with the pathology development, including immune response, ion transport, cardiac muscle processes and nervous system. An in-depth study of the transcription factors binding sites in the differentially methylated regions corroborated the importance of these processes. We also conducted a methylation study on blood to identify potential biomarkers for CCC. Our data revealed 198 differentially methylated positions (DMPs) that could serve as biomarkers of the disease, of which 61 are associated with disease severity.","journal":"medRxiv","year":2021,"id":222166,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":715688,"name":"Bárbara Maria Ianni","orcid":"0000-0002-1588-5492","position":1,"is_corresponding":false},{"id":823305,"name":"Laurie Laugier","orcid":null,"position":2,"is_corresponding":false},{"id":716297,"name":"Amanda Farage Frade","orcid":null,"position":3,"is_corresponding":false},{"id":618346,"name":"João Paulo Silva Nunes","orcid":"0000-0003-4355-6669","position":4,"is_corresponding":false},{"id":822860,"name":"Priscila Camillo Teixeira","orcid":"0000-0002-9698-4563","position":5,"is_corresponding":false},{"id":715690,"name":"Charles Mady","orcid":"0000-0002-8838-199X","position":6,"is_corresponding":false},{"id":525530,"name":"Ludmila Rodrigues Pinto Ferreira","orcid":"0000-0001-9944-6691","position":7,"is_corresponding":false},{"id":822861,"name":"Quentin Ferré","orcid":"0000-0003-4750-0355","position":8,"is_corresponding":false},{"id":822862,"name":"Ronaldo Honorato Barros Santos","orcid":"0009-0002-7033-8616","position":9,"is_corresponding":false},{"id":823306,"name":"Andréia Kuramoto","orcid":null,"position":10,"is_corresponding":false},{"id":822863,"name":"Sandrine Cabantous","orcid":"0000-0003-0381-8679","position":11,"is_corresponding":false},{"id":822864,"name":"Samuel Padovani Steffen","orcid":"0000-0001-6553-2305","position":12,"is_corresponding":false},{"id":823307,"name":"Antonio Noedir Stolf","orcid":null,"position":13,"is_corresponding":false},{"id":822865,"name":"Pablo Maria Alberto Pomerantzeff","orcid":"0000-0003-0566-1038","position":14,"is_corresponding":false},{"id":822866,"name":"Alfredo Inácio Fiorelli","orcid":"0000-0002-6213-6902","position":15,"is_corresponding":false},{"id":822867,"name":"Edimar Alcides Bocchi","orcid":"0000-0001-9204-485X","position":16,"is_corresponding":false},{"id":822868,"name":"Cristina Wide Pissetti","orcid":"0000-0002-5534-8544","position":17,"is_corresponding":false},{"id":823308,"name":"Bruno Saba","orcid":null,"position":18,"is_corresponding":false},{"id":711937,"name":"Darlan da Silva Cândido","orcid":"0000-0002-5080-3130","position":19,"is_corresponding":false},{"id":822869,"name":"Fabrício C. 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