{"doi":"10.1101/2021.12.10.472143","title":"Neuroimaging alterations and relapse in early-stage psychosis","abstract":"ABSTRACT Recent reports have indicated that the occurrence of symptom exacerbation in early-stage psychosis could result in brain changes. Such a symptom exacerbation is frequently called relapse, which underlies a poorer disease outcome. Thus, it is important to identify neuroimaging alterations that are specifically seen in patients who experience relapse in early-stage psychosis. We hypothesized that this specific patient group may be more homogenous in disease-associated signatures likely to be linked to relapse, compared with the overall patient group. Such sub-stratified patient group and neuroimaging signatures would be useful for the biological understanding of relapse. To address this goal, we conducted a cross-sectional study (85 patients with early-stage psychosis and 94 healthy controls) with the use of medical records in a retrospective manner. To define the specific sub-group with the past experience of relapse, we used hospitalization due to psychotic symptom exacerbation, according to many publications that used this factor as a proxy for relapse. By examining resting-state functional connectivity (FC) for the study subjects, we validated our hypothesis and defined 131 FCs possibly associated with relapse. Through these studies, 3 brain regions (the thalamus, precentral gyrus, and dorsal anterior cingulate cortex) were underscored.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":222252,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9528,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":823407,"name":"Anisha Nagpal","orcid":"0000-0001-7111-9322","position":1,"is_corresponding":false},{"id":727622,"name":"Semra Etyemez","orcid":"0000-0001-6114-5631","position":2,"is_corresponding":false},{"id":727619,"name":"Zui Narita","orcid":"0000-0001-7022-2141","position":3,"is_corresponding":false},{"id":823408,"name":"Anna Ross","orcid":"0000-0002-5114-5686","position":4,"is_corresponding":false},{"id":728114,"name":"Rebecca L. Schaub","orcid":null,"position":5,"is_corresponding":false},{"id":239036,"name":"Nicola G. Cascella","orcid":null,"position":6,"is_corresponding":false},{"id":240713,"name":"Jennifer M. Coughlin","orcid":"0000-0002-2514-9640","position":7,"is_corresponding":false},{"id":62411,"name":"Gerald Nestadt","orcid":"0000-0001-9461-5249","position":8,"is_corresponding":false},{"id":728113,"name":"Frederik C. Nucifora","orcid":null,"position":9,"is_corresponding":false},{"id":355942,"name":"Thomas W. Sedlak","orcid":"0000-0002-6791-9105","position":10,"is_corresponding":false},{"id":728116,"name":"Koko Ishizuka","orcid":null,"position":11,"is_corresponding":false},{"id":227761,"name":"Vince D. Calhoun","orcid":"0000-0001-9058-0747","position":12,"is_corresponding":false},{"id":315438,"name":"Andréia V. Faria","orcid":"0000-0002-1673-002X","position":13,"is_corresponding":false},{"id":823409,"name":"Kun Yang","orcid":"0000-0002-0273-2198","position":14,"is_corresponding":false},{"id":33854,"name":"Akira Sawa","orcid":"0000-0003-1401-3008","position":15,"is_corresponding":false},{"id":556009,"name":"Marina Mihaljević","orcid":"0000-0003-3415-8706","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:54:03.549854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}