{"doi":"10.1101/2021.12.05.471332","title":"Functional Anatomy of the TDP-43 Redox Sensor","abstract":"Abstract TAR binding protein 43 (TDP-43) is an RNA binding protein that assists in the maturation, export and sub-cellular localization of mRNA. The carboxyl terminal 153 residues of TDP-43 are of low sequence complexity and allow for self-association of the protein in a manner leading to its phase separation from an aqueous environment. These interactions assist TDP-43 in forming cytoplasmic RNA granules involved in the transport of mRNA for localized translation. Self-association of the TDP-43 low complexity (LC) domain is facilitated by a region of twenty five residues that are of extreme evolutionary conservation. The molecular basis for self-adherence of the protein through this region has been illuminated by a combination of structural and biochemical studies, allowing definition of a morphologically specific cross-β structure predicted to be weakly assembled by main chain hydrogen bonds. In this study we have investigated the importance of individual, Pauling hydrogen bonds hypothesized to facilitate self-adherence of the TDP-43 LC domain.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":228190,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9602,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":832989,"name":"Lily Sumrow","orcid":"0000-0003-4285-6387","position":1,"is_corresponding":false},{"id":645095,"name":"Lillian B. Sutherland","orcid":"0000-0002-3155-9646","position":2,"is_corresponding":false},{"id":342864,"name":"Daifei Liu","orcid":"0000-0002-0700-5926","position":3,"is_corresponding":false},{"id":257961,"name":"Tian Qin","orcid":"0000-0001-7225-3224","position":4,"is_corresponding":false},{"id":342865,"name":"Steven L. McKnight","orcid":"0000-0002-9014-9364","position":5,"is_corresponding":false},{"id":645094,"name":"Glen Liszczak","orcid":"0000-0001-8194-5281","position":6,"is_corresponding":false},{"id":342863,"name":"Xiaoming Zhou","orcid":"0000-0002-6840-973X","position":0,"is_corresponding":true}],"reference_count":23,"raw_metadata":null,"created_at":"2026-07-18T23:54:50.414605Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}