{"doi":"10.1101/2021.11.13.468487","title":"Vγ usage distinguishes pro- and anti-tumor intestinal γδ T cell subsets","abstract":"Abstract γδ T cells physiologically scan the intestinal epithelium, representing a substantial fraction of infiltrating lymphocytes in colorectal cancer (CRC), albeit their role in CRC remains unclear. Using murine CRC models, we found that most γδ T cells in pre- or non-tumor colon express Vγ1 + or Vγ7 + and exhibit a cytotoxic profile. Targeting these γδ T cell subsets, as well as conditionally interfering with γδ T cell function at early stages of tumorigenesis led to heightened tumor development, suggesting anti-CRC functions for Vγ1 + and Vγ7 + subsets. In contrast, RORγt + γδ T cell subsets, including Vγ4 + and microbiotadependent Vγ6 + , accumulated during CRC progression. Conditional deletion of RORγt or Vγ chains revealed redundant roles for IL-17–producing Vγ4 + and Vγ6 + γδ T cells in promoting tumor growth. Our results uncover pro- and anti-tumor roles for γδ T cell subsets.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":227480,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513926,"name":"Patrick W. Darcy","orcid":null,"position":1,"is_corresponding":false},{"id":698199,"name":"Iasha Z. Khan","orcid":"0000-0002-8994-9110","position":2,"is_corresponding":false},{"id":831392,"name":"Olawale Eleso","orcid":"0000-0002-9210-9585","position":3,"is_corresponding":false},{"id":831828,"name":"Caixia Zhu","orcid":null,"position":4,"is_corresponding":false},{"id":831393,"name":"Marina Schernthanner","orcid":"0000-0002-6394-6050","position":5,"is_corresponding":false},{"id":831394,"name":"Ainsley Lockhart","orcid":"0000-0003-0304-4618","position":6,"is_corresponding":false},{"id":831395,"name":"Aubrey Reed","orcid":"0000-0002-8613-3167","position":7,"is_corresponding":false},{"id":295163,"name":"Juliana Bortolatto","orcid":"0000-0001-8779-5464","position":8,"is_corresponding":false},{"id":217900,"name":"Tiago B. R. Castro","orcid":"0000-0002-0359-0611","position":9,"is_corresponding":false},{"id":295160,"name":"Angelina M. Bilate","orcid":"0000-0003-4575-786X","position":10,"is_corresponding":false},{"id":577434,"name":"Sergei I. Grivennikov","orcid":"0000-0003-2987-0555","position":11,"is_corresponding":false},{"id":66190,"name":"Daniel Mucida","orcid":"0000-0002-0000-0452","position":12,"is_corresponding":false},{"id":66192,"name":"Bernardo Sgarbi Reis","orcid":"0000-0002-6841-116X","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:54:42.179886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}