{"doi":"10.1101/2021.10.11.464022","title":"Specific <i>N</i> -glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning","abstract":"Abstract N -glycans are molecularly diverse sugars borne by over 70% of proteins transiting the secretory pathway and have been implicated in protein folding, stability, and localization. Mutations in genes important for N -glycosylation result in congenital disorders of glycosylation that are often associated with intellectual disability. Here, we show that structurally distinct N -glycans regulate the activity of an extracellular protein complex involved in patterning of somatosensory dendrites in Caenorhabditis elegans . Specifically, aman-2/Golgi alpha-mannosidase II , a conserved key enzyme in the biosynthesis of specific N -glycans regulates the activity of the Menorin adhesion complex without obviously affecting protein stability and localization of its components. AMAN-2 functions cell-autonomously to ensure decoration of the neuronal transmembrane receptor DMA-1/LRR-TM with high-mannose/hybrid N -glycans. Moreover, distinct types of N -glycans on specific N -glycosylation sites regulate the DMA-1/LRR-TM receptor, which together with three other extracellular proteins forms the Menorin adhesion complex. In summary, specific N -glycan structures regulate dendrite patterning by coordinating the activity of an extracellular adhesion complex suggesting that the molecular diversity of N -glycans can contribute to developmental specificity in the nervous system.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":227174,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":729649,"name":"Nelson J. Ramírez-Suárez","orcid":"0000-0001-7394-860X","position":1,"is_corresponding":false},{"id":830994,"name":"Carlos A. Díaz-Balzac","orcid":"0000-0002-4723-1282","position":2,"is_corresponding":false},{"id":577233,"name":"Hannes E. Bülow","orcid":"0000-0002-6271-0572","position":3,"is_corresponding":false},{"id":729648,"name":"Maisha Rahman","orcid":"0000-0003-1795-0814","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-18T23:54:42.179886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}