{"doi":"10.1101/2021.09.18.460869","title":"Myelin Imaging Using Dual-echo 3D Ultra-short Echo Time MRI with Rosette k-Space Pattern","abstract":"Abstract Purpose This study aimed to develop a new 3D dual-echo rosette k-space trajectory, specifically for ultra-short echo time (UTE) magnetic resonance imaging (MRI) applications. The direct imaging of the myelin bilayer, which has ultra-short transverse relaxation time (uT 2 ), was acquired to test the performance of the proposed UTE sequence. Theory and Methods The rosette trajectory was developed based on rotations of a ‘petal-like’ pattern in the k x -k y plane, with oscillated extensions in k z -direction for 3D coverage. Five healthy volunteers were recruited and underwent ten dual-echo 3D rosette UTE scans with various echo times (TEs). Dual-exponential complex model fitting was performed on the magnitude data to separate uT 2 signals, with the output of uT 2 fraction, uT 2 value, and long T 2 value. Results The reconstructed images’ signal contrast between whiate matter (WM) and grey matter (GM) increased with longer TEs. The WM regions had higher uT 2 fraction values than GM (10.9%±1.9% vs. 5.7%±2.4%). The uT 2 value was approximately 0.15 milliseconds in WM. Conclusion The higher uT 2 fraction value in WM compared to GM demonstrated the ability of the proposed sequence to capture rapidly decaying signals.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":219367,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":817951,"name":"Ali Çağlar Özen","orcid":"0000-0003-3536-0826","position":1,"is_corresponding":false},{"id":818623,"name":"Antonia Sunjar","orcid":null,"position":2,"is_corresponding":false},{"id":817952,"name":"Serhat İlbey","orcid":"0000-0002-3574-4320","position":3,"is_corresponding":false},{"id":568691,"name":"Riyi Shi","orcid":"0000-0002-7297-9428","position":4,"is_corresponding":false},{"id":817953,"name":"Mark Chiew","orcid":"0000-0001-6272-8783","position":5,"is_corresponding":false},{"id":407457,"name":"Uzay E. Emir","orcid":"0000-0001-5376-0431","position":6,"is_corresponding":false},{"id":407452,"name":"Xin Shen","orcid":"0000-0003-0184-8751","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T23:53:38.409982Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}