{"doi":"10.1101/2021.09.18.459450","title":"SL-Cloud: A Computational Resource to Support Synthetic Lethal Interaction Discovery","abstract":"Summary Synthetic lethal interactions (SLIs), genetic interactions in which the simultaneous inactivation of two genes leads to a lethal phenotype, are promising targets for therapeutic intervention in cancer, as exemplified by the recent success of PARP inhibitors in treating BRCA1/2-deficient tumors. We present SL-Cloud, an integrated resource and framework to facilitate the prediction of context-specific SLIs by using cloud-based technologies. This resource addresses two main challenges related to SLI inference: the need to wrangle and preprocess large multi-omic datasets and the multiple comparable prediction approaches available. We demonstrate the utility of this resource by using a set of DNA damage repair genes as the basis for predicting potential SLI partners, using multiple computational strategies. Context-specific synthetic lethality potential can also be compared using the framework. We demonstrate various use cases for our cloud-based computational resource and the utility of this approach for customizable and extensible computational inference of SLIs.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":226557,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6796,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":6469,"name":"Guangrong Qin","orcid":"0000-0001-8836-1246","position":1,"is_corresponding":false},{"id":296563,"name":"Taek‐Kyun Kim","orcid":null,"position":2,"is_corresponding":false},{"id":824247,"name":"Boris Aguilar","orcid":"0000-0002-9840-5908","position":3,"is_corresponding":false},{"id":457945,"name":"Christopher J. Kemp","orcid":null,"position":4,"is_corresponding":false},{"id":52020,"name":"Nyasha Chambwe","orcid":"0000-0002-2812-0122","position":5,"is_corresponding":false},{"id":237257,"name":"Ilya Shmulevich","orcid":"0000-0002-4410-8780","position":6,"is_corresponding":false},{"id":626014,"name":"Bahar Tercan","orcid":"0000-0002-5332-264X","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T23:54:34.185847Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}