{"doi":"10.1101/2021.09.09.459504","title":"Differential antibody dynamics to SARS-CoV-2 infection and vaccination","abstract":"ABSTRACT Optimal immune responses furnish long-lasting (durable) antibodies protective across dynamically mutating viral variants (broad). To assess robustness of mRNA vaccine-induced immunity, we compared antibody durability and breadth after SARS-CoV-2 infection and vaccination. While vaccination delivered robust initial virus-specific antibodies with some cross-variant coverage, pre-variant SARS-CoV-2 infection-induced antibodies, while modest in magnitude, showed highly stable long-term antibody dynamics. Vaccination after infection induced maximal antibody magnitudes with enhanced longitudinal stability while infection-naïve vaccinee antibodies fell with time to post-infection-alone levels. The composition of antibody neutralizing activity to variant relative to original virus also differed between groups, with infection-induced antibodies demonstrating greater relative breadth. Differential antibody durability trajectories favored COVID-19-recovered subjects with dual memory B cell features of greater early antibody somatic mutation and cross-coronavirus reactivity. By illuminating an infection-mediated antibody breadth advantage and an anti-SARS-CoV-2 antibody durability-enhancing function conferred by recalled immunity, these findings may serve as guides for ongoing vaccine strategy improvement.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":213465,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9449,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245202,"name":"Pei Tong","orcid":"0000-0003-4301-6857","position":1,"is_corresponding":false},{"id":630735,"name":"Noah B. Whiteman","orcid":"0000-0003-3629-0671","position":2,"is_corresponding":false},{"id":339314,"name":"Ali Sanjari Moghaddam","orcid":"0000-0002-9292-7377","position":3,"is_corresponding":false},{"id":106728,"name":"Adam Zuiani","orcid":"0000-0002-2625-6595","position":4,"is_corresponding":false},{"id":106731,"name":"Shaghayegh Habibi","orcid":"0000-0002-5209-9220","position":5,"is_corresponding":false},{"id":245203,"name":"Avneesh Gautam","orcid":"0000-0003-1745-5530","position":6,"is_corresponding":false},{"id":106135,"name":"Tianshu Xiao","orcid":"0000-0003-1287-1228","position":7,"is_corresponding":false},{"id":106133,"name":"Yongfei Cai","orcid":"0000-0002-3628-3802","position":8,"is_corresponding":false},{"id":106141,"name":"Bing Chen","orcid":"0000-0002-8625-1657","position":9,"is_corresponding":false},{"id":106756,"name":"Duane R. Wesemann","orcid":"0000-0002-6690-944X","position":10,"is_corresponding":false},{"id":805488,"name":"Yuezhou Chen","orcid":"0000-0002-9138-7081","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:52:36.886828Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}