{"doi":"10.1101/2021.09.01.458573","title":"Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production","abstract":"Abstract Recent lineage tracing analyses revealed multipotent progenitors (MPP) to be major functional contributors to steady-state hematopoiesis ( 1–6 ). However, we are still lacking a precise resolution of myeloid differentiation trajectories and cellular heterogeneity in MPPs. Here, we found that myeloid-biased MPP3 ( 2, 3 ) are functionally and molecularly heterogeneous, with a distinct subset of myeloid-primed secretory cells with high endoplasmic reticulum (ER) volume and Fc γ R expression. We show that Fc γ R + /ER high MPP3 are a transitional population for rapid production of granulocyte/macrophage progenitors (GMP), which directly amplify myelopoiesis through inflammation-triggered secretion of cytokines in the local bone marrow (BM) microenvironment. Our results identify a novel regulatory function for a subset of secretory MPP3 that controls myeloid differentiation through lineage-priming and cytokine production, and act as a self-reinforcing amplification compartment in stress and disease conditions. One-Sentence Summary A secretory subset of multipotent hematopoietic progenitors augment myelopoiesis in stress and diseases conditions.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":219256,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9463,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":517907,"name":"Hyojung Paik","orcid":"0000-0002-5803-0670","position":1,"is_corresponding":false},{"id":637707,"name":"Si Yi Zhang","orcid":null,"position":2,"is_corresponding":false},{"id":3009,"name":"Jonathan Chen","orcid":"0000-0001-6074-9302","position":3,"is_corresponding":false},{"id":817795,"name":"Matthew R. Warr","orcid":"0000-0003-0710-3785","position":4,"is_corresponding":false},{"id":35664,"name":"Rong Fan","orcid":"0000-0001-7805-8059","position":5,"is_corresponding":false},{"id":29970,"name":"Emmanuelle Passegué","orcid":"0000-0002-3516-297X","position":6,"is_corresponding":false},{"id":550808,"name":"Yoon-A Kang","orcid":"0000-0002-0978-5348","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T23:53:38.409982Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}