{"doi":"10.1101/2021.09.01.458535","title":"Out-of-distribution prediction with disentangled representations for single-cell RNA sequencing data","abstract":"Learning robust representations can help uncover underlying biological variation in scRNA-seq data. Disentangled representation learning is one approach to obtain such informative as well as interpretable representations. Here, we learn disentangled representations of scRNA-seq data using β variational autoencoder ( β -VAE) and apply the model for out-of-distribution (OOD) prediction. We demonstrate accurate gene expression predictions for cell-types absent from training in a perturbation and a developmental dataset. We further show that β -VAE outperforms a state-of-the-art disentanglement method for scRNA-seq in OOD prediction while achieving better disentanglement performance.","journal":null,"year":2021,"id":1323,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0603,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-09-02","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":12138,"name":"Leander Dony","orcid":"0000-0001-5697-6991","position":1,"is_corresponding":false},{"id":16464,"name":"Harshita Agarwala","orcid":null,"position":2,"is_corresponding":false},{"id":42,"name":"Fabian Joachim Theis","orcid":"0000-0002-2419-1943","position":4,"is_corresponding":false},{"id":1694,"name":"Mohammad Lotfollahi","orcid":"0000-0001-6858-7985","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}