{"doi":"10.1101/2021.08.15.456403","title":"Polymer microparticles prolong delivery of the 15-PGDH inhibitor SW033291","abstract":"Abstract As the prevalence of age-related fibrotic diseases continues to increase, novel antifibrotic therapies are emerging to address clinical needs. However, many novel therapeutics for managing chronic fibrosis are small-molecule drugs that require frequent dosing to attain effective concentrations. While bolus parenteral administrations have become standard clinical practice, an extended delivery platform would achieve steady state concentrations over a longer time period with fewer administrations. This study lays the foundation for the development of a sustained release platform for the delivery of (+)SW033291, a potent, small-molecule inhibitor of the 15-hydroxyprostaglandin dehydrogenase (15-PGDH) enzyme, which has previously demonstrated efficacy in a murine model of pulmonary fibrosis. Herein, we leverage fine-tuned cyclodextrin microparticles – specifically β-CD microparticles (β-CD MPs) – to extend the delivery of 15-PGDH inhibitor, (+)SW033291, to over one week. Graphical Abstract","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":226322,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9455,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259164,"name":"Nathan A. Rohner","orcid":"0000-0002-9112-2382","position":1,"is_corresponding":false},{"id":488777,"name":"Julianne Smith","orcid":"0000-0002-2536-5933","position":2,"is_corresponding":false},{"id":7771,"name":"Jessica A. Kilgore","orcid":"0000-0001-9138-2099","position":3,"is_corresponding":false},{"id":7763,"name":"Noelle S. Williams","orcid":"0000-0003-1894-5742","position":4,"is_corresponding":false},{"id":2243,"name":"Sanford D. Markowitz","orcid":"0000-0001-5369-5254","position":5,"is_corresponding":false},{"id":339745,"name":"Horst A. von Recum","orcid":"0000-0002-9323-8100","position":6,"is_corresponding":false},{"id":299403,"name":"Amar D. Desai","orcid":"0000-0001-6873-3217","position":7,"is_corresponding":false},{"id":572365,"name":"Alan B. Dogan","orcid":"0000-0002-2166-6595","position":0,"is_corresponding":true}],"reference_count":25,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:54:34.185847Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}