{"doi":"10.1101/2021.08.03.454066","title":"Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response","abstract":"Abstract Recent investigation of the meninges, specifically the dura layer, has highlighted its importance in CNS immune surveillance beyond a purely structural role. However, most of our understanding of the meninges stems from the use of pre-clinical models rather than human samples. In this study, we use single cell RNA-sequencing to perform the first characterization of both non-tumor-associated human dura and meningioma samples. First, we reveal a complex immune microenvironment in human dura that is transcriptionally distinct from that of meningioma. In addition, through T cell receptor sequencing, we show significant TCR overlap between matched dura and meningioma samples. We also identify a functionally heterogeneous population of non-immune cell types and report copy-number variant heterogeneity within our meningioma samples. Our comprehensive investigation of both the immune and non-immune cell landscapes of human dura and meningioma at a single cell resolution provide new insight into previously uncharacterized roles of human dura.","journal":"bioRxiv (Cold Spring Harbor Laboratory)","year":2021,"id":216759,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8425,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297953,"name":"Jay A. Bowman-Kirigin","orcid":"0000-0002-7687-3727","position":1,"is_corresponding":false},{"id":649416,"name":"Rupen Desai","orcid":"0000-0002-2052-7243","position":2,"is_corresponding":false},{"id":813716,"name":"Pujan R. Patel","orcid":null,"position":3,"is_corresponding":false},{"id":294378,"name":"Bhuvic Patel","orcid":"0000-0001-8062-7310","position":4,"is_corresponding":false},{"id":376024,"name":"Saad M. Khan","orcid":"0000-0002-1385-2056","position":5,"is_corresponding":false},{"id":225123,"name":"Diane E. Bender","orcid":"0000-0002-8311-4390","position":6,"is_corresponding":false},{"id":494222,"name":"M. Caleb Marlin","orcid":"0000-0003-0453-5355","position":7,"is_corresponding":false},{"id":813046,"name":"Jingxian Liu","orcid":"0000-0003-4194-5273","position":8,"is_corresponding":false},{"id":298058,"name":"Joshua W. Osbun","orcid":"0000-0003-4308-9669","position":9,"is_corresponding":false},{"id":294381,"name":"Eric C. Leuthardt","orcid":"0000-0003-4154-3135","position":10,"is_corresponding":false},{"id":611834,"name":"Michael R. Chicoine","orcid":"0000-0002-0689-8603","position":11,"is_corresponding":false},{"id":649702,"name":"Ralph G. Dacey","orcid":"0000-0002-9181-6413","position":12,"is_corresponding":false},{"id":394789,"name":"Gregory J. Zipfel","orcid":"0000-0003-2737-9084","position":13,"is_corresponding":false},{"id":294383,"name":"Albert H. Kim","orcid":"0000-0002-1751-8493","position":14,"is_corresponding":false},{"id":626358,"name":"Allegra A. Petti","orcid":"0000-0001-6884-6107","position":15,"is_corresponding":false},{"id":231268,"name":"Gavin P. Dunn","orcid":"0000-0001-9302-4834","position":16,"is_corresponding":false},{"id":649700,"name":"Anthony Z. Wang","orcid":"0000-0003-4824-9908","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-18T23:53:15.868165Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}